Protein Info for HEPCGN_17530 in Escherichia coli ECOR38

Name: ttdT
Annotation: L-tartrate/succinate antiporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 487 transmembrane" amino acids 7 to 27 (21 residues), see Phobius details amino acids 33 to 49 (17 residues), see Phobius details amino acids 56 to 74 (19 residues), see Phobius details amino acids 93 to 116 (24 residues), see Phobius details amino acids 137 to 154 (18 residues), see Phobius details amino acids 192 to 219 (28 residues), see Phobius details amino acids 234 to 257 (24 residues), see Phobius details amino acids 289 to 328 (40 residues), see Phobius details amino acids 337 to 361 (25 residues), see Phobius details amino acids 368 to 390 (23 residues), see Phobius details amino acids 393 to 415 (23 residues), see Phobius details amino acids 420 to 442 (23 residues), see Phobius details amino acids 461 to 485 (25 residues), see Phobius details PF00939: Na_sulph_symp" amino acids 5 to 486 (482 residues), 647.6 bits, see alignment E=1.4e-198 TIGR00785: transporter, divalent anion:Na+ symporter (DASS) family" amino acids 24 to 482 (459 residues), 557.9 bits, see alignment E=7.5e-172 PF03600: CitMHS" amino acids 45 to 416 (372 residues), 78.7 bits, see alignment E=4.7e-26

Best Hits

Swiss-Prot: 100% identical to TTDT_ECO57: L-tartrate/succinate antiporter (ttdT) from Escherichia coli O157:H7

KEGG orthology group: K11106, L-tartrate/succinate antiporter (inferred from 100% identity to ect:ECIAI39_3559)

MetaCyc: 99% identical to L-tartrate:succinate antiporter (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-127

Predicted SEED Role

"Citrate Succinate antiporter (TC 2.A.47.3.2)" (TC 2.A.47.3.2)

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (487 amino acids)

>HEPCGN_17530 L-tartrate/succinate antiporter (Escherichia coli ECOR38)
MKPSTEWWRYLAPLAVIAIIALIPVPAGLESHTWLYFAVFTGVIVGLILEPVPGAVVAMV
GISIIAILSPWLLFSPEQLAQPGFKFTAKSLSWAVSGFSNSVIWLIFAAFMFGTGYEKTG
LGRRIALILVKKMGHRTLFLGYAVMFSELILAPVTPSNSARGAGIIYPIIRNLPPLYQSQ
PNDSSSRSIGSYIMWMGIVADCVTSAIFLTAMAPNLLLIGLMKSASHATLSWGDWFLGML
PLSILLVLLVPWMAYVLYPPVLKSGDQVPRWAETELQAMGPLCSREKRMLGLMVGALVLW
IFGGDYIDAAMVGYSVVALMLLLRIICWDDIVSNKAAWNVFFWLASLITLATGLNNTGFI
SWFGKLLAGSLSGYSPTMVMVALIVVFYLLRYFFASATAYTSALAPMMIAAALAMPEIPL
PVFCLMVGAAIGLGSILTPYATGPSPIYYGSGYLPTADYWRLGAIFGLIFLVLLVITGLL
WMPVVLL