Protein Info for HEPCGN_13980 in Escherichia coli ECOR38

Annotation: type III cell invasion protein SipB

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 593 transmembrane" amino acids 319 to 339 (21 residues), see Phobius details amino acids 346 to 372 (27 residues), see Phobius details amino acids 422 to 454 (33 residues), see Phobius details amino acids 516 to 537 (22 residues), see Phobius details PF16535: T3SSipB" amino acids 85 to 225 (141 residues), 38.4 bits, see alignment E=7.9e-14

Best Hits

KEGG orthology group: K13285, invasin B (inferred from 100% identity to ect:ECIAI39_4254)

Predicted SEED Role

"cell invasion protein SipB" in subsystem Salmonella invasion locus or Type III secretion systems, extended

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (593 amino acids)

>HEPCGN_13980 type III cell invasion protein SipB (Escherichia coli ECOR38)
MSAPITGQTITFEQISETLRTQYSDAEKRLQDSSKTQVDPMRLNKNPKSLDNDIRARLEN
KPMLAPPEIQVSDSDNATTAKTNDARLTMILGNLTGIADQDITKRLHNNLDSTLLRHEMA
HNKFRELSDAYSSSLDDAQKADDIMHQANNNYNAVDKKVQSLEKKVNTLNQELSQLQPGD
PQYNKVLTQKNAAEKTLTLSLQKKSLAEQSLNTAIMDADAAIGQSMEIFDEIQQQEQINN
FTTNICLTQENQKNRNATATFILLITSVMEVIGDTNCDSIKNQSEVMKEINHVRENKLNE
TARKYTTTTKVLKIVNECVTVVTFAVSAVLIVVGLLAAVPSGGSSIAGALALIGGIAGAV
VLGVDITCQIALGTTATGWILGKVVEGLSAAIKTVDPTLLAITALLDVIGVDQNTIELVK
SIYASAAASIVMATVMIGAAVICSVAIGAVVSALSKTAAEEVTKEITSTIKSTIESIINS
VSKNIIKVLDSVCSVLQTSAVVLKLIAKISNGLEKIGLLICAIATSTMNCFVAGNSADMA
ILQQDMSNLSKTREQMLSVLQRVDKTVEQEVSQMVRVLQHRTEALKFASHSIV