Protein Info for HEPCGN_10185 in Escherichia coli ECOR38

Name: chpS
Annotation: type II toxin-antitoxin system antitoxin ChpS

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 25 50 83 PF04014: MazE_antitoxin" amino acids 5 to 49 (45 residues), 44.1 bits, see alignment E=8.2e-16

Best Hits

Swiss-Prot: 95% identical to CHPS_ECOLI: Antitoxin ChpS (chpS) from Escherichia coli (strain K12)

KEGG orthology group: None (inferred from 100% identity to ecm:EcSMS35_4702)

MetaCyc: 95% identical to ChpS antitoxin of the ChpB-ChpS toxin-antitoxin system (Escherichia coli K-12 substr. MG1655)

Predicted SEED Role

"Programmed cell death antitoxin ChpS" in subsystem MazEF toxin-antitoxing (programmed cell death) system

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (83 amino acids)

>HEPCGN_10185 type II toxin-antitoxin system antitoxin ChpS (Escherichia coli ECOR38)
MRITIKRWGNSSGMVIPNVVMKELNLRPGQSVEAQVSNNQLILTPISRRYSLDELLAQCD
MNATELSEQDVWGKSTPAGDEIW