Protein Info for GFF952 in Sphingobium sp. HT1-2

Annotation: Gamma-glutamyl phosphate reductase (EC 1.2.1.41)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00171: Aldedh
  • amino acids 16 to 286 (271 residues), 50.7 bits, E=5.4e-18
• TIGR00407: glutamate-5-semialdehyde dehydrogenase
  • amino acids 19 to 410 (392 residues), 454.2 bits, E=1.8e-140

Best Hits

Swiss-Prot: 72% identical to PROA_SPHAL: Gamma-glutamyl phosphate reductase (proA) from Sphingopyxis alaskensis (strain DSM 13593 / LMG 18877 / RB2256)

KEGG orthology group: K00147, glutamate-5-semialdehyde dehydrogenase [EC: 1.2.1.41] (inferred from 86% identity to sjp:SJA_C1-33790)

MetaCyc: 45% identical to glutamate-5-semialdehyde dehydrogenase (Escherichia coli K-12 substr. MG1655)
Glutamate-5-semialdehyde dehydrogenase. [EC: 1.2.1.41]

Predicted SEED Role

"Gamma-glutamyl phosphate reductase (EC 1.2.1.41)" in subsystem Proline Synthesis (EC 1.2.1.41)

MetaCyc Pathways

• L-proline biosynthesis I (from L-glutamate) (4/4 steps found)
• L-ornithine biosynthesis II (3/3 steps found)
• L-citrulline biosynthesis (6/8 steps found)
• superpathway of L-citrulline metabolism (8/12 steps found)
• L-N^δ-acetylornithine biosynthesis (4/7 steps found)

KEGG Metabolic Maps

• Arginine and proline metabolism
• Urea cycle and metabolism of amino groups

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.2.1.41

Protein Sequence (421 amino acids)

>GFF952 Gamma-glutamyl phosphate reductase (EC 1.2.1.41) (Sphingobium sp. HT1-2)
MNDLTQTPEMLIAQMGARARRAAALLAPAGDAQKVDALRRAAQALRDQAPAILAANARDM
DNGIDNGLSAAMLDRLRLDEDRIASMAAGVDQVATLDNPLGSVIDSSVRPNGLELSRVRV
PLGVIGIIYESRPNVTADAAALCLRAGNAVILRGGSEAKESNRAIHAAMAEGIAAAGLPA
EAVQLIPTTDRAVVGALLRASDFVDLIVPRGGKSLVARVQEEARVPVLAHLDGINHSYVD
GAADPAMAESLVLNAKLRRTGVCGSTETVLIDRAYGHAPALVKALLDAKCEVRGDEAVQA
MDDRVIAASDEDWDTEYLDAIVSIRLVDGVEEAIAHIAAHASHHTDAIITEDAAVAERFL
NAVDSAIVMWNASTQFADGGEFGLGAEIGISTGRLHARGPVALEGLTTYKWIVRGRGQAR
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