Protein Info for GFF949 in Xanthobacter sp. DMC5

Annotation: Peptidyl-prolyl cis-trans isomerase D

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 631 transmembrane" amino acids 12 to 32 (21 residues), see Phobius details PF13623: SurA_N_2" amino acids 3 to 142 (140 residues), 98.8 bits, see alignment E=6.8e-32 PF13624: SurA_N_3" amino acids 3 to 165 (163 residues), 149.9 bits, see alignment E=1.4e-47 PF13145: Rotamase_2" amino acids 249 to 369 (121 residues), 96.1 bits, see alignment E=6.6e-31 PF00639: Rotamase" amino acids 281 to 354 (74 residues), 26.5 bits, see alignment E=2.7e-09

Best Hits

KEGG orthology group: K03770, peptidyl-prolyl cis-trans isomerase D [EC: 5.2.1.8] (inferred from 78% identity to xau:Xaut_4379)

Predicted SEED Role

"Peptidyl-prolyl cis-trans isomerase PpiD (EC 5.2.1.8)" (EC 5.2.1.8)

Isozymes

Compare fitness of predicted isozymes for: 5.2.1.8

Use Curated BLAST to search for 5.2.1.8

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (631 amino acids)

>GFF949 Peptidyl-prolyl cis-trans isomerase D (Xanthobacter sp. DMC5)
MVLQTLRKGASGWIAKIFLVVLTLSFVVWGIADVFRGMGASAVASVGGTEISAQVFRQQY
LDQLQRISRQAGRAITPEQARAFGLDRQVLNQMIADATLDAEAARLSLAISDAQIAREIA
DNPNFRAPGAKAFDPGYFQQILRSNGLTEQRFVASEKQRQVRDQLLQSLGAGVSVPQVLL
EAVNRFEGETRTASYIRVTPAAAGTLPAPTEDALRAYFDAHKLAFRAPEYRKISVLALTP
AALSAGITVTDEDAKAEYDRTIARFGKPETREVQQIVFTSAADAATAEEKIKAGATFADI
AAARGLTAKDTDLGLVAKSAILDPKIAEAAFSLADGAVSGPVEGRFGTALVHVTKIVPGA
FQPFELVKPQIVAELQLDKAKRIILDMHDKVEDERASGATLQETAQKLGLKLASFDVDRS
GRDPAGASVEVPGGADVISGAFAAQPGVETDTVQLPQGGGFVWYETAAITPARDRTFEEA
KEAVTARYTEAETEKAVEAKAKELMDKAKAGTPLAQVSAEADIPLQIAEGLHRGRADGPF
SAESVTSVFDVKEGGFGIALGTPEPDRIVFQVTKVEIPQQMPPDTSRVTQELSRQLENDV
LVQYLAAIQKELGVKINERLFAQAVGSNPAN