Protein Info for GFF9 in Variovorax sp. SCN45

Annotation: CzcABC family efflux RND transporter, transmembrane protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1031 signal peptide" amino acids 1 to 31 (31 residues), see Phobius details transmembrane" amino acids 334 to 353 (20 residues), see Phobius details amino acids 360 to 380 (21 residues), see Phobius details amino acids 386 to 409 (24 residues), see Phobius details amino acids 429 to 451 (23 residues), see Phobius details amino acids 468 to 491 (24 residues), see Phobius details amino acids 520 to 541 (22 residues), see Phobius details amino acids 858 to 877 (20 residues), see Phobius details amino acids 884 to 905 (22 residues), see Phobius details amino acids 911 to 933 (23 residues), see Phobius details amino acids 960 to 980 (21 residues), see Phobius details amino acids 988 to 1014 (27 residues), see Phobius details TIGR00914: heavy metal efflux pump, CzcA family" amino acids 1 to 1012 (1012 residues), 874.7 bits, see alignment E=4.3e-267 PF00873: ACR_tran" amino acids 6 to 1014 (1009 residues), 808.4 bits, see alignment E=8.9e-247 PF03176: MMPL" amino acids 325 to 497 (173 residues), 28 bits, see alignment E=1.1e-10

Best Hits

KEGG orthology group: K07239, heavy-metal exporter, HME family (inferred from 64% identity to llo:LLO_3380)

Predicted SEED Role

"Cobalt-zinc-cadmium resistance protein CzcA; Cation efflux system protein CusA"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1031 amino acids)

>GFF9 CzcABC family efflux RND transporter, transmembrane protein (Variovorax sp. SCN45)
MINLIITQFFRRRHLVWAMSIALVLFGAWSWTQMTVEAYPDLGDVTVQVTTQVNGLASEE
IEQQITTPLERALSNTPGLASIRSSSTFGLSLITLTFKDGTDDYFARQRVTERIGQVSLP
SGAQPGLDPVAGPAGEIYRYTLESDTKNLMELSEIQRWIVIPGLRQVAGVVNITNFGGFT
KEFQLELDPAALQKYGLALSDVVTAINNNSANAGGGRIARGEQSYVVRGIGLITSLDDLG
AVVVSQSGGSPVLVRDLGRLQFGHQERGGILGKDRNPDTIEGIVLMLKYENPSRVLEGVH
KKIDELQAQLAPMGVKIVPYIDRDDLVKLTVDKVTHTVLEGMALVCFVLILFLGSPRSAV
VAAVAIPMSLVTVFIVMHFTRMPANLFSLGAIDFGIIVDGAIVVMEAILRRREEEPHATL
TEGNILETVSHVSGPIFFATLIIITAYFPLFAFERAEGKLFKPMAFTVGYALVGALLCAI
TLIPSLAYVALRKPMKPFVNKPLVWLTGAYRRVLGHLLRVPAIAYALSIAALAAVAILGA
TAGREFLPDIDEGALWLQVQLPSGLSLDKASEMTAELRHVLLEYPEVSYVVTQLGRNDDG
TDPWTPSHVEVPVGLKPYSEWPAGVNKAAFVRTLNERFSKMPGFDVGISQPIIDGVNDAV
GGAHSPLVLRIYGDDLKESRRIGNEIVDLLHTVRGTASASLFQEPPIPQVVIKLDREAAA
RLGVNANDVASLVQTGMGGAPVITVYSGDRTYNVTVKLPKSAKSGTEAIGSLLLNGAGGA
KIPLSQVASVKLQTGESTISHELNSRQITVRIDNRGRDLASYLVEAQDRIAKDVKFDHAK
FRLQWAGQFENQQRAQARLAVSLLIVVSIMAVLLFFQFGKIRHVALILGVVPMATLGGLI
AVHVAGETLNVATAVGFIALFGVSIQNGIIMVANFRRVRGEGLALEASVLEGATERLRPV
LMTATVASIGMLPAALATGVGTDVQRGLATVVVGGLVVSTLLTLFILPTLFFALERLFER
KGWGVRSRRDR