Protein Info for GFF875 in Sphingobium sp. HT1-2

Annotation: Efflux ABC transporter, permease/ATP-binding protein mlr7818

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 614 transmembrane" amino acids 37 to 58 (22 residues), see Phobius details amino acids 72 to 93 (22 residues), see Phobius details amino acids 151 to 174 (24 residues), see Phobius details amino acids 180 to 199 (20 residues), see Phobius details amino acids 262 to 285 (24 residues), see Phobius details amino acids 299 to 318 (20 residues), see Phobius details PF00664: ABC_membrane" amino acids 39 to 311 (273 residues), 141.5 bits, see alignment E=4.4e-45 PF00005: ABC_tran" amino acids 373 to 522 (150 residues), 116.7 bits, see alignment E=1.3e-37

Best Hits

Swiss-Prot: 66% identical to ATM1_NOVAD: ATM1-type heavy metal exporter (atm1) from Novosphingobium aromaticivorans (strain ATCC 700278 / DSM 12444 / CIP 105152 / NBRC 16084 / F199)

KEGG orthology group: None (inferred from 90% identity to sch:Sphch_1972)

Predicted SEED Role

"Lipid A export ATP-binding/permease protein MsbA" in subsystem ZZ gjo need homes

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (614 amino acids)

>GFF875 Efflux ABC transporter, permease/ATP-binding protein mlr7818 (Sphingobium sp. HT1-2)
MPPATPDSTPLPPAWATLRRFIPYLWPADAPALRRRVAVALALVALAKVVTLAMPFAYKG
AIDRMAPGLEPAAGLAMALVVAYAGARFGGVLFDNLRNAIFEKVGQEAGRRLADDVFVHL
HRLSLRFHLDRRTGAVTKIVERGTKSIDTMLYFLLFNIAPTVLELLAVCAIFLVKFGPGL
VAATLAMVALYIWFTRLVTEWRNQLRRDMVDMDTSAVAHAVDSLLNFETVKYFGAEEREA
RRYGTAMRRYAKAAVKSENSLAWLNIGQSLITNLMMGGAMAYTVWGWSRGQFSTGDVVLV
NTLLSQLFRPLDLLGMVYRTIRQGLIDMEAMYKLIDTETEVADAPGAPVLQVAGGAVRFD
SVRFGYDPEREILHGVSFAVPAGKTLAIVGPSGAGKSTIARILFRFYDIQGGTVSIDGQD
IAAVTQQSLRAAIGIVPQDMVLFNDTVGYNIGYGREGARQEEIEAAAKAASIHDFIMSLP
QGYDTRVGERGLKLSGGEKQRVAIARTLLKDPPVLVLDEATSALDSRTETEIQTVLRDIS
RKRTTLVVAHRLSTVVDADEIIVLDAGRIVERGRHADLVRADGLYATMWARQATERDDMP
QEPGIEDMFEVAPQ