Protein Info for GFF869 in Xanthobacter sp. DMC5

Annotation: Lipid A export ATP-binding/permease protein MsbA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 616 transmembrane" amino acids 36 to 58 (23 residues), see Phobius details amino acids 70 to 91 (22 residues), see Phobius details amino acids 148 to 170 (23 residues), see Phobius details amino acids 176 to 193 (18 residues), see Phobius details amino acids 263 to 282 (20 residues), see Phobius details amino acids 290 to 306 (17 residues), see Phobius details PF00664: ABC_membrane" amino acids 51 to 302 (252 residues), 119 bits, see alignment E=3.1e-38 PF00005: ABC_tran" amino acids 371 to 519 (149 residues), 107.5 bits, see alignment E=8.3e-35

Best Hits

Swiss-Prot: 45% identical to Y4GM_SINFN: Uncharacterized ABC transporter ATP-binding protein y4gM (NGR_a03510) from Sinorhizobium fredii (strain NBRC 101917 / NGR234)

KEGG orthology group: K06147, ATP-binding cassette, subfamily B, bacterial (inferred from 84% identity to xau:Xaut_4230)

Predicted SEED Role

"Lipid A export ATP-binding/permease protein MsbA" in subsystem ZZ gjo need homes

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (616 amino acids)

>GFF869 Lipid A export ATP-binding/permease protein MsbA (Xanthobacter sp. DMC5)
MNAKAAQRLGPPPSTDETNAVLRRLLLSDGRKHWKGYVLAFVFMGTMAACTAGLAYLMND
AVNAIFVHPTPAAVWAVSGIVMVLSIIKGASAYGQSITMARIGNRVVADNQKRAFDRLLL
QDAAYFGHRHTAEITTRFTAGASGARGALDLVVTSIGRDALSLVMLAGVAFVQDPFLAVI
ALVVMPAAVIGTRKLIKKAKTIFTTGFTSGVKLSSIVMEVFQGIRTVKAYTLEPVMRERT
HKFIDDVEINANRLVRTQAKSSPLMETLGGLAIGGVILYAGYNVIELGRSPGQFFSVLTA
LLLAYEPAKRLSRLHVELVSHVMGARMLFDLLDAPAPDADSSGVGALPRPRGRVEFKDVV
FAYRPGENVLRSLDLVAEPGRTTALVGQSGGGKTTIINLIERFYDPQSGAVLIDDVDTRS
VSRTSVRASVALVSQDVYLFSGTIRENIGFGRPGASEEEIVAAAKAAHAHPFIMSFENGY
DTAVGEHGAQLSGGQRQRIAIARAFLKNAPILLLDEATAALDSESEAEVQKALAELAHER
TTIVIAHRLQTVVRADRICVIEGGRVVESGTHDELIARRGRYYGFYFAQFAHESENADSS
VGSAVESGPDGDLLRA