Protein Info for GFF835 in Sphingobium sp. HT1-2

Annotation: Xaa-Pro aminopeptidase (EC 3.4.11.9)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 593 PF01321: Creatinase_N" amino acids 7 to 138 (132 residues), 58.8 bits, see alignment E=1.7e-19 PF16189: Creatinase_N_2" amino acids 148 to 306 (159 residues), 153.5 bits, see alignment E=1e-48 PF00557: Peptidase_M24" amino acids 310 to 524 (215 residues), 185.8 bits, see alignment E=1.8e-58 PF16188: Peptidase_M24_C" amino acids 533 to 593 (61 residues), 75.5 bits, see alignment E=5e-25

Best Hits

KEGG orthology group: K01262, Xaa-Pro aminopeptidase [EC: 3.4.11.9] (inferred from 87% identity to sjp:SJA_C1-01520)

Predicted SEED Role

"Xaa-Pro aminopeptidase (EC 3.4.11.9)" (EC 3.4.11.9)

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.4.11.9

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (593 amino acids)

>GFF835 Xaa-Pro aminopeptidase (EC 3.4.11.9) (Sphingobium sp. HT1-2)
MSSYEDRLKALRAQLVRQKLDGFVVPLTDEHMSEYVGAYAQRLAWLTGFQGSAGSAVVLP
EEAAIFVDGRYTLQVREQVDGAHWQYESVPQTSIAAWLKDHAIEGARIGYDSWLHTRAWV
KQATEALAQKGAELVAVDTNPVDAVWPDRPAPSDAKLVVHADRYAGKNAAEKRADIADWL
VSKKADAAVLSALDSIAWAFNIRGKDVERTPVALAYAIVHADATADLYVAPEKMDEAVAK
HLGNAVRIHARAAFADALADLQGKTVVADPERAVAAIFEALDAGGAQILSLRDPAVLPKA
IKNDTEIAGHKAAQERDGAALSRFLHWIAVEAPKGGLTELSASDRLEAFRKDTGLLEDLS
FDTISGAGPNGAVVHYRVEEKTNRPIETGSFYLVDSGGQYRDGTTDVTRTIAIGTPSEEM
KQRFTLVLKGHIALARAVFPVGTRGGQLDVLARQYLWAQGLDYAHGTGHGVGSFLSVHEG
PQRIATFGGGDEPLVAGMILSNEPGYYKTGEYGIRIENLVLVEERAIAGGEKPMLGFETL
TFAPIDRNAIATDLLDAGERAWVDAYHAQVLAVVGPQLDGEALAWLQSACAPL