Protein Info for GFF825 in Sphingobium sp. HT1-2

Annotation: L-threonine 3-O-phosphate decarboxylase (EC 4.1.1.81)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00155: Aminotran_1_2
  • amino acids 117 to 312 (196 residues), 101 bits, E=4.3e-33

Best Hits

KEGG orthology group: K02225, cobalamin biosynthetic protein CobC (inferred from 58% identity to nar:Saro_0325)

Predicted SEED Role

"L-threonine 3-O-phosphate decarboxylase (EC 4.1.1.81)" in subsystem Cobalamin synthesis or Coenzyme B12 biosynthesis (EC 4.1.1.81)

MetaCyc Pathways

• adenosylcobalamin biosynthesis II (aerobic) (28/33 steps found)
• superpathway of L-threonine metabolism (13/18 steps found)
• aminopropanol phosphate biosynthesis I (1/2 steps found)
• adenosylcobalamin biosynthesis I (anaerobic) (25/36 steps found)

KEGG Metabolic Maps

• Porphyrin and chlorophyll metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.1.1.81

Protein Sequence (327 amino acids)

>GFF825 L-threonine 3-O-phosphate decarboxylase (EC 4.1.1.81) (Sphingobium sp. HT1-2)
MTTRWTWHGGGVAAASAHFGGAPESWLDLSTGINPHAWPGAAEQVIDWRALPDEQGLRAL
EQAAADHFGVAADHVCALPGTEVGLRLVGALLDGSVRHASPAYRTHGAMVQGAAPVDLDR
LDEADGQTLILANPNNPDGRIHGVADLLALLDRRGPDGWLVVDEAFADGHPGISLAPFVA
DDRRLMLLRSFGKFFGLAGLRLGFLVAPRAIIARVRDRLGAWPVSAAAIAIGTAAYRDRA
WIEAMRDQLQREAQALDTLLLGHGYQPIGQSSLFRLIETPHAMALFERLAGLAILTRPFE
AQPHWLRIGLPADAMGLARLERALRHG