Protein Info for GFF824 in Sphingobium sp. HT1-2
Annotation: Adenosylcobinamide-phosphate synthase (EC 6.3.1.10)
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 50% identical to COBD_RHOCA: Cobalamin biosynthesis protein CobD (cobD) from Rhodobacter capsulatus
KEGG orthology group: K02227, adenosylcobinamide-phosphate synthase CobD [EC: 6.3.1.10] (inferred from 67% identity to nar:Saro_0324)Predicted SEED Role
"Adenosylcobinamide-phosphate synthase (EC 6.3.1.10)" (EC 6.3.1.10)
MetaCyc Pathways
- adenosylcobalamin biosynthesis II (aerobic) (28/33 steps found)
- adenosylcobinamide-GDP biosynthesis from cobyrinate a,c-diamide (6/6 steps found)
- superpathway of adenosylcobalamin salvage from cobinamide II (8/9 steps found)
- adenosylcobinamide-GDP salvage from cobinamide II (5/6 steps found)
- adenosylcobalamin biosynthesis I (anaerobic) (25/36 steps found)
KEGG Metabolic Maps
Isozymes
No predicted isozymesUse Curated BLAST to search for 6.3.1.10
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Compare to protein structures
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (317 amino acids)
>GFF824 Adenosylcobinamide-phosphate synthase (EC 6.3.1.10) (Sphingobium sp. HT1-2) MADPVALLALALDAAVGWPAALYRRIGHPVGGFARLIDHCAARWNDPARSALARKMGGIA TLLLLLSVAGGGGWLVQYLLRLWLPEPWSWLLIGLLAYPALALRSLYSHVRAVHRALAAD DLSAAREAVGMIVGRDTQSLDESGVTRAAIESLAESFCDGVVAPFFWLLLLGLPGVWAYK AVNTADSMIGHREAPWGPFGWAAARTDDLMNLIPARLAGCLLCLAGGGGWRVMWRDARNH ASPNAGWPEAAMAGALDLRLAGPIRYDDVRHDKPWIGSGRSDADPLDLRWALAIYVQACL LLWLVAGLQALFAGDMI