Protein Info for GFF798 in Variovorax sp. SCN45

Annotation: Cardiolipin synthase (EC 2.7.8.-) phosphatidylethanolamine-utilizing, bacterial type ClsC

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF13091: PLDc_2
  • amino acids 87 to 236 (150 residues), 45.3 bits, E=7.7e-16
  • amino acids 344 to 480 (137 residues), 67.3 bits, E=1.3e-22
• PF00614: PLDc
  • amino acids 433 to 458 (26 residues), 27.1 bits, see alignment (E = 3.2e-10)

Best Hits

KEGG orthology group: None (inferred from 86% identity to vpe:Varpa_3877)

Predicted SEED Role

"Cardiolipin synthetase (EC 2.7.8.-)" in subsystem Glycerolipid and Glycerophospholipid Metabolism in Bacteria (EC 2.7.8.-)

MetaCyc Pathways

• cardiolipin biosynthesis II (3/3 steps found)
• cardiolipin and phosphatidylethanolamine biosynthesis (Xanthomonas) (3/4 steps found)
• superpathway of cardiolipin biosynthesis (bacteria) (9/13 steps found)

KEGG Metabolic Maps

• Aminophosphonate metabolism
• Glycerophospholipid metabolism
• High-mannose type N-glycan biosynthesis
• Nucleotide sugars metabolism
• Sphingolipid metabolism

Isozymes

Compare fitness of predicted isozymes for: 2.7.8.-

Use Curated BLAST to search for 2.7.8.-

Protein Sequence (542 amino acids)

>GFF798 Cardiolipin synthase (EC 2.7.8.-) phosphatidylethanolamine-utilizing, bacterial type ClsC (Variovorax sp. SCN45)
MPHSFCRATRVPRARWLTWLLAGIAALIVTGCAGLPTDVQRKPSTAITNGADTTLGRLVQ
AAAPPGEPLSGFRLLPMPQFSLHARIELARRAQRSIDVQYYLVQNDETGRYLLRALRDAA
DRGVRVRLLVDDLYTAGADPLFTSFAAHPNVEVRLFNPFPAGRDRFGTRWAWSILDFDRV
HRRMHNKLYVVDNAIGVMGGRNIANEYFLRDGGSNFIDIDTLVAGAVVPRLSSLFDMYWN
SPYVYPIESLVPSTGETPRQLRERFDKLTTGPSQLHPEEPDSTDLLGNNPLAKDLDAGAL
KLVWARAEAYADAPAKALGPTEEARGLPADESKDSVLYNVRRYVRGAENEVLQTTPYLIP
GRGGMESIRTVRGNGVAYSIVTNSLAATDESLVHIGYRRYRPEMLRLGVELYELSPKRVE
QTKRFGMYGSASGRLHGKSAVIDRRIVFIGSMNFDPRSMLHNTEVGIFIFSPQIAQQLTS
LIGFIRLDGAYQLQLGPTGAIEWVSPASGDAADTILHQEPETDFWSRWKLDLLAPLVPES
LL