Protein Info for GFF7624 in Variovorax sp. SCN45

Annotation: Thiamine-monophosphate kinase (EC 2.7.4.16)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00892: EamA
  • amino acids 9 to 122 (114 residues), 39.7 bits, E=5.8e-14
• PF00586: AIRS
  • amino acids 121 to 204 (84 residues), 69.3 bits, E=3.8e-23

Predicted SEED Role

"Thiamine-monophosphate kinase (EC 2.7.4.16)" in subsystem Thiamin biosynthesis (EC 2.7.4.16)

MetaCyc Pathways

• superpathway of thiamine diphosphate biosynthesis II (9/11 steps found)
• thiamine diphosphate biosynthesis I (E. coli) (2/2 steps found)
• thiamine diphosphate biosynthesis II (Bacillus) (2/2 steps found)
• thiamine diphosphate salvage II (4/5 steps found)
• thiamine diphosphate salvage V (2/3 steps found)
• superpathway of thiamine diphosphate biosynthesis I (7/10 steps found)
• thiamine diphosphate salvage I (1/2 steps found)

KEGG Metabolic Maps

• Thiamine metabolism

Isozymes

Compare fitness of predicted isozymes for: 2.7.4.16

Use Curated BLAST to search for 2.7.4.16

Protein Sequence (223 amino acids)

>GFF7624 Thiamine-monophosphate kinase (EC 2.7.4.16) (Variovorax sp. SCN45)
VPAADSRPALIQLLIAELLIGSVGVFVHESGQDAITAVLFRCVFGVVFLLAWGWARGLFR
GLLGEGALIRSAIFSGVLLVLNWVALFAGMARSSIGVATMVYHFFPFVVLGLAALFYGER
TRAADIGWKALAANLSDLAAMGAEPAWCTLSLSLPAGDAAARVAFVEGFADGFLELAARH
RVALVGGDTTRGPLSVCVTVLGFVEPGWALRRDAARVDDEIWV