Protein Info for GFF7406 in Variovorax sp. SCN45

Annotation: Cysteine dioxygenase (EC 1.13.11.20) / Rhodanese-related sulfurtransferase, 4 domains

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 740 PF00581: Rhodanese" amino acids 209 to 302 (94 residues), 36.2 bits, see alignment E=3.5e-13 amino acids 332 to 425 (94 residues), 35 bits, see alignment E=8.2e-13 amino acids 485 to 553 (69 residues), 25.9 bits, see alignment E=5.5e-10 amino acids 582 to 672 (91 residues), 30.9 bits, see alignment E=1.6e-11

Best Hits

KEGG orthology group: None (inferred from 87% identity to vap:Vapar_1882)

Predicted SEED Role

"Rhodanese-related sulfurtransferase"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (740 amino acids)

>GFF7406 Cysteine dioxygenase (EC 1.13.11.20) / Rhodanese-related sulfurtransferase, 4 domains (Variovorax sp. SCN45)
MSLTDLPVDTAGNDIASARTRAIDAFLAQARGLLARSQDRAALQSVADALIALGQRKSLF
PAAHFPIDAARPAQVYRLAEDVDGGFALYLSAGLAGKAQPPHDHTTWAVIAGVEGNERNV
LYRREKTGDAARDALVQTGTVDVAAGSAVVLLPDDVHTIELVGGQDGRHLHFYGRALQLL
DRRVVFEGTEGGSFRHFAPPKNIRHPAITPQALRAALADGEEIALLDVRETGVFVRSHIL
LAASAPLWRLEVLIDRLVPRRATRIVLADADESLAHEAAAKLVRLGWRNVSVLAGGTQGW
AAAGYELFSGSNVPSKAFGEVIEHEKHTPWISVDDLHERVKRGDDIVVVDSRTPEEFADF
SLPFAHSLPGAELVYRIQELAPRPETLVVVNCAGRTRSIVGAQTLIDAGIPNKVVSLKDG
TMAWLLAGRELAHGRAAPLPEPGEQTRESARARAEDVAARAGVRRIDAETLARFEAEADE
RSLYRFDVRTRQEYEAGHLEGWRWAPGGQLVQATDEYVGTRHARIVLADWDGVRALTTGA
WLAQLGGHEVFVLSPPALPVRVLGPEPVRVLSLREFTPDIAPREAAAALEAGTAVVFDVE
RRSAFERRHVAGARFAVPDRLQEFTADLPPSQAIVLTSSDGVLARTVAAELAARTGRTVR
AIAGGTQAWSAARLPTSAGSEGVLTGDDDHWYSPYAHTDLAKRDAGFKQYLDWEIGLVAQ
LEREGDVGIRLVTPGGAAAS