Protein Info for GFF719 in Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868

Annotation: HMP-PP hydrolase (pyridoxal phosphatase) Cof, detected in genetic screen for thiamin metabolic genes (PMID:15292217)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 176 PF08282: Hydrolase_3" amino acids 2 to 164 (163 residues), 103 bits, see alignment E=2.3e-33 PF05116: S6PP" amino acids 41 to 155 (115 residues), 47 bits, see alignment E=2.6e-16

Best Hits

KEGG orthology group: None (inferred from 97% identity to see:SNSL254_A0908)

Predicted SEED Role

"HMP-PP hydrolase (pyridoxal phosphatase) Cof, detected in genetic screen for thiamin metabolic genes (PMID:15292217)"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (176 amino acids)

>GFF719 HMP-PP hydrolase (pyridoxal phosphatase) Cof, detected in genetic screen for thiamin metabolic genes (PMID:15292217) (Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868)
LLKDKQLNFVACGLQSAYVSENAPEAFVTLMAKHYHRLKPVKDYQEIDDVLFKFSLNLPD
EQIPLVIDKLHVTLDGIMKPVTSGFGFIDLIIPGLHKANGISRLLKRWDLPPQNMVAIGD
SGNDAEMLKMAHYSFAMDNAAENIKQIARYATDNNKHEGALNVIQAVLENKVPFTL