Protein Info for GFF7143 in Variovorax sp. SCN45

Annotation: Permease of the drug/metabolite transporter (DMT) superfamily

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 322 signal peptide" amino acids 1 to 17 (17 residues), see Phobius details transmembrane" amino acids 34 to 53 (20 residues), see Phobius details amino acids 65 to 85 (21 residues), see Phobius details amino acids 91 to 111 (21 residues), see Phobius details amino acids 118 to 137 (20 residues), see Phobius details amino acids 143 to 163 (21 residues), see Phobius details amino acids 172 to 194 (23 residues), see Phobius details amino acids 206 to 224 (19 residues), see Phobius details amino acids 236 to 255 (20 residues), see Phobius details amino acids 260 to 277 (18 residues), see Phobius details PF00892: EamA" amino acids 8 to 134 (127 residues), 54.7 bits, see alignment E=6.7e-19 amino acids 145 to 276 (132 residues), 84 bits, see alignment E=6e-28

Best Hits

Swiss-Prot: 45% identical to PECM_DICD3: Protein PecM (pecM) from Dickeya dadantii (strain 3937)

KEGG orthology group: None (inferred from 89% identity to vpe:Varpa_5943)

Predicted SEED Role

"Permease of the drug/metabolite transporter (DMT) superfamily" in subsystem Queuosine-Archaeosine Biosynthesis

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (322 amino acids)

>GFF7143 Permease of the drug/metabolite transporter (DMT) superfamily (Variovorax sp. SCN45)
MTSRTTDVLLTASAPAIWGSTYIVTTELLPPNYPLTVALLRALPAGLLLLLIVRKLPERA
WWGRIFVLGALNFSMLWAMLFLAAYRLPGGVAATITSVQPLLVVFLASAFLGAPVRALSV
VAAAVGIGGVALLVLTPNAALDAVGIAAAIAAAVSMAFGTVLSRRWQPPVSALTFTAWQL
TAGGLLLLPVALLLEPPLPALTPHNWIGFGWLGLVGAALTYIVWFRGVARLEPSAIAPLA
FLSPVTAVILGWALLEQSLSAWQVLGIGIVIASIWLSQRAQRGGQPWQNRAATLPGGIRS
CPSSPSASRAASSPPRASRRPR