Protein Info for GFF7062 in Variovorax sp. SCN45

Annotation: probable carboxylesterase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 220 PF02230: Abhydrolase_2" amino acids 12 to 215 (204 residues), 182.9 bits, see alignment E=2.8e-57 PF03959: FSH1" amino acids 17 to 203 (187 residues), 22.8 bits, see alignment E=2.4e-08 PF01738: DLH" amino acids 76 to 202 (127 residues), 29.2 bits, see alignment E=2.4e-10

Best Hits

Swiss-Prot: 42% identical to APTH1_YARLI: Acyl-protein thioesterase 1 (YALI0A18337g) from Yarrowia lipolytica (strain CLIB 122 / E 150)

KEGG orthology group: K06999, (no description) (inferred from 92% identity to vap:Vapar_3639)

Predicted SEED Role

"probable carboxylesterase"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (220 amino acids)

>GFF7062 probable carboxylesterase (Variovorax sp. SCN45)
MSRPPIEIETAPNPTATVIVMHGLGADGNDFVPIANELDLAAVGPVRFVFPNAPVIPVTI
NGGYQMPAWYDIAVADLAAREDEAGLRRSQAAIETLIASEKVRGIAADRIVVAGFSQGCA
MSLMTGLRHTERLAGIVGLSGYLPIAATTAAERHAANHETPVFLAHGRQDPVVPLAAAVR
SRDALTALGYTVEWHEYTMAHSVCMEEIADLNRFLLRVLG