Protein Info for GFF706 in Sphingobium sp. HT1-2

Annotation: Inosine-uridine preferring nucleoside hydrolase (EC 3.2.2.1)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF01156: IU_nuc_hydro
  • amino acids 35 to 361 (327 residues), 185.1 bits, E=1.2e-58

Best Hits

KEGG orthology group: None (inferred from 54% identity to xcv:XCV0316)

Predicted SEED Role

"Inosine-uridine preferring nucleoside hydrolase (EC 3.2.2.1)" in subsystem Purine conversions or Queuosine-Archaeosine Biosynthesis (EC 3.2.2.1)

MetaCyc Pathways

• adenosine nucleotides degradation I (7/8 steps found)
• adenine and adenosine salvage II (2/2 steps found)
• guanine and guanosine salvage II (2/2 steps found)
• purine nucleotides degradation I (plants) (9/12 steps found)
• guanosine nucleotides degradation I (3/4 steps found)
• guanosine nucleotides degradation II (3/4 steps found)
• superpathway of guanosine nucleotides degradation (plants) (4/6 steps found)
• superpathway of purines degradation in plants (9/18 steps found)

KEGG Metabolic Maps

• Nicotinate and nicotinamide metabolism
• Purine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.2.2.1

Protein Sequence (378 amino acids)

>GFF706 Inosine-uridine preferring nucleoside hydrolase (EC 3.2.2.1) (Sphingobium sp. HT1-2)
MRTMKIMLGALALMLGVQGSNAKPAAPATPKRLVIVDDDMIGLNGVPLLLLQSPDVEVLG
ITTTSGSVWRDTATAYALRTLEILGRTDVPVVPGATFPLLNSAEATKRWEGQYGRLVFKG
PWTDYWPGDTIQEHPGSTDPTKVPDLPIGNPRTKPSAEIAAAFLVRMVKAHPGEITLFAT
GPMTNIAIAQSLDPSFAANVKEILYMGGSLAPHQVLEGPSAEQFAREFVNSPRREFNIRW
DPEAAKIFAHAPWKKITMIPVDPSTGTQWTRAFLDELKPAHTPLTDLFQTGLEPGYPMWD
EIVAMAWLNPEIVTKDETLWVDFETSQTAAYGDTLSWTESYRPHLGEQAQRVILSVDRAK
MEAAMARLYMRPVGKAAK