Protein Info for GFF701 in Xanthobacter sp. DMC5

Annotation: Heme A synthase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 358 transmembrane" amino acids 23 to 42 (20 residues), see Phobius details amino acids 106 to 124 (19 residues), see Phobius details amino acids 136 to 154 (19 residues), see Phobius details amino acids 167 to 187 (21 residues), see Phobius details amino acids 208 to 230 (23 residues), see Phobius details amino acids 272 to 289 (18 residues), see Phobius details amino acids 300 to 319 (20 residues), see Phobius details amino acids 327 to 348 (22 residues), see Phobius details PF02628: COX15-CtaA" amino acids 23 to 340 (318 residues), 359.6 bits, see alignment E=7.1e-112

Best Hits

Swiss-Prot: 82% identical to CTAA_XANP2: Heme A synthase (ctaA) from Xanthobacter autotrophicus (strain ATCC BAA-1158 / Py2)

KEGG orthology group: K02259, cytochrome c oxidase subunit XV assembly protein (inferred from 82% identity to xau:Xaut_4338)

Predicted SEED Role

"Heme A synthase, cytochrome oxidase biogenesis protein Cox15-CtaA" in subsystem Biogenesis of cytochrome c oxidases

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (358 amino acids)

>GFF701 Heme A synthase (Xanthobacter sp. DMC5)
MSHAEAVTLIADRPRPGIKAVRLWLYFVAALIVAMVVVGGATRLTESGLSITEWKPVTGA
LPPMSQGDWQAEFDRYKAIPQYEILNKGMGLEAFKRIYWWEWGHRLLGRVIGFAFFLPFL
YFAFRGVLRGSLLAKCLGLFALGGLQGAVGWWMVASGLTERVSVSQYRLAVHLTLACVIL
AAIVAVARSLAGEGRQMVNGRVRLTARVLVALVLVQIFAGGLVAGLDAGMAYNTWPLMDG
HFIPGAEQLGAMSPFWRNLFENALTVQFDHRMVAYALWALALVHALDCMRGGGRAARRAW
VLFALVTAQATLGILTLIHQVPIDIALAHQFGATIVLIFAVVHVSGLGAPEAAKAVTA