Protein Info for GFF6961 in Variovorax sp. SCN45

Annotation: Cytochrome c oxidase (cbb3-type) subunit CcoP (EC 1.9.3.1)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 305 transmembrane" amino acids 12 to 32 (21 residues), see Phobius details amino acids 61 to 81 (21 residues), see Phobius details PF14715: FixP_N" amino acids 41 to 87 (47 residues), 76 bits, see alignment 2.2e-25 TIGR00782: cytochrome c oxidase, cbb3-type, subunit III" amino acids 42 to 298 (257 residues), 261.6 bits, see alignment E=4.3e-82 PF13442: Cytochrome_CBB3" amino acids 132 to 206 (75 residues), 48.3 bits, see alignment E=1.6e-16 amino acids 228 to 293 (66 residues), 38.8 bits, see alignment E=1.4e-13 PF00034: Cytochrom_C" amino acids 134 to 210 (77 residues), 36.8 bits, see alignment E=1.3e-12 amino acids 222 to 296 (75 residues), 25.9 bits, see alignment E=3.1e-09

Best Hits

Swiss-Prot: 60% identical to CCOP_RUBGE: Cbb3-type cytochrome c oxidase subunit CcoP (ccoP) from Rubrivivax gelatinosus

KEGG orthology group: K00406, cb-type cytochrome c oxidase subunit III [EC: 1.9.3.1] (inferred from 78% identity to vap:Vapar_2821)

Predicted SEED Role

"Cytochrome c oxidase subunit CcoP (EC 1.9.3.1)" in subsystem Terminal cytochrome C oxidases (EC 1.9.3.1)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.9.3.1

Use Curated BLAST to search for 1.9.3.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (305 amino acids)

>GFF6961 Cytochrome c oxidase (cbb3-type) subunit CcoP (EC 1.9.3.1) (Variovorax sp. SCN45)
MSDFISRFWSNYVAVISLLSILGCVILLWLTARKRVAPSADNTTGHVWDGDLREANNPLP
MWWVGLFVLTIVFGLGYLAVFPGLGSFRGQSDWTSRGEYEAEVAKATQELAPVYAKYTAM
PVEEIARDPQAHAIGERLFMGNCAQCHGSDARGSKGFPDLTDKDWLYGGTPERITESITK
GRVGVMPPMAAAVGTSDDVKNVANYVLSLSGEPHDSVRAGLGKSKFTVCVACHGVGGVGN
QTLGAPNLSDKIWLHGYGEAAIIQMINSGKRNEMPAQERRLTEAQIRMVASYVWGLSNST
AAAKP