Protein Info for GFF6914 in Variovorax sp. SCN45

Annotation: Cytochrome c-type biogenesis protein DsbD, protein-disulfide reductase (EC 1.8.1.8)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 724 transmembrane" amino acids 323 to 348 (26 residues), see Phobius details amino acids 369 to 392 (24 residues), see Phobius details amino acids 406 to 428 (23 residues), see Phobius details amino acids 449 to 475 (27 residues), see Phobius details amino acids 482 to 507 (26 residues), see Phobius details amino acids 522 to 540 (19 residues), see Phobius details amino acids 547 to 566 (20 residues), see Phobius details amino acids 573 to 592 (20 residues), see Phobius details PF11412: DsbD_N" amino acids 34 to 150 (117 residues), 68.2 bits, see alignment E=1e-22 PF02683: DsbD_TM" amino acids 325 to 536 (212 residues), 58.3 bits, see alignment E=1.1e-19 PF13899: Thioredoxin_7" amino acids 614 to 700 (87 residues), 74 bits, see alignment E=1.3e-24

Best Hits

KEGG orthology group: None (inferred from 87% identity to vpe:Varpa_0749)

Predicted SEED Role

"Cytochrome c-type biogenesis protein DsbD, protein-disulfide reductase (EC 1.8.1.8)" in subsystem Biogenesis of c-type cytochromes or Periplasmic disulfide interchange (EC 1.8.1.8)

Isozymes

Compare fitness of predicted isozymes for: 1.8.1.8

Use Curated BLAST to search for 1.8.1.8

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (724 amino acids)

>GFF6914 Cytochrome c-type biogenesis protein DsbD, protein-disulfide reductase (EC 1.8.1.8) (Variovorax sp. SCN45)
MPAAAQLASKPGAVVTTPHVRAELIAHAPDGVAPGSPVWVGLQITHQPEWHTYWKNAGDS
GLPTEMTWTLPAGVSTGEIAWPVPEKIPVGSLANYGYENTVLLPVPLEVSSLYKPPMALG
GGTPAMDIQLKASWLVCRKECIPEEGSFSLSLPLQGSTALHKAEFDTAQAGQPQPLAQAG
AVQVDGHSLKVRLDGLPAAAQGKTLEFFPETPEVIRTAAVSGKDWTQSWQGGTWTATIPL
ADQRSASPNVMPLVVALAPSDRQAGQPIAWRAESPVTGAWPAAAVAQRAEVSSALQAALT
ANAANAAAKAGGAELPAPSSTTFMAALLGALLGGLLLNLMPCVFPILAIKVLGFARQAGN
DSAHRKAGLAYTGGVMLSFLALGGAMLALRAAGAGLGWGFQLQSPAVVAALAALFTLIGL
NLAGVFEFGRAAPSSICSAQAKHPLANDFLSGVLAVVIASPCTAPFMGASLGFAISLPAG
QALLLFAALGFGLALPYLAASFVPAVARLLPKPGPWMHTLRRLLAFPMFATVAWLVWVLG
QQSGIDGAGTLLALLVCMAAIVWALTLQGRTRIVIAAVMIAFTAVLTAAIGRNVLQVVEP
ARLASAAEAGQPQRWQPWSAERVAELSGAGRPVFIDFTAAWCVTCQYNKKSTLSDAQVLA
DFDAKQVAMLRADWTRRDPAITAALTALGRSGVPVYVLQAPGKPPVVLTEILGKDEVRAA
IAAL