Protein Info for GFF6876 in Variovorax sp. SCN45
Annotation: Aminotransferase, DegT/DnrJ/EryC1/StrS family
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 54% identical to ERBS_SACEN: Erythromycin biosynthesis sensory transduction protein EryC1 (eryC1) from Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 / NRRL 2338)
KEGG orthology group: K00837, [EC: 2.6.1.-] (inferred from 58% identity to gur:Gura_3190)MetaCyc: 54% identical to dTDP-3-oxo-3,4,6-trideoxy-alpha-D-glucopyranose transaminase monomer (Saccharopolyspora erythraea NRRL 2338)
RXN-12768 [EC: 2.6.1.106]
Predicted SEED Role
"Aminotransferase"
MetaCyc Pathways
- dTDP-D-desosamine biosynthesis (3/6 steps found)
- superpathway of erythromycin biosynthesis (3/19 steps found)
- superpathway of megalomicin A biosynthesis (4/22 steps found)
KEGG Metabolic Maps
- Aminophosphonate metabolism
- Arginine and proline metabolism
- Caprolactam degradation
- Lysine biosynthesis
- Lysine degradation
- Methionine metabolism
- Nucleotide sugars metabolism
Isozymes
Compare fitness of predicted isozymes for: 2.6.1.-
Use Curated BLAST to search for 2.6.1.- or 2.6.1.106
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Compare to protein structures
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (366 amino acids)
>GFF6876 Aminotransferase, DegT/DnrJ/EryC1/StrS family (Variovorax sp. SCN45) MIPFFDIHAGHAEMADDFTQAFSKVMKSGHVIMGGELVAFENEFAAYCGAKHCIGVGNGL DALALTLRARGIKAGDEVLVPSQTFIATWLGVSMVGATPVPVEIDPATYLLDPARIKEKL TSRTKAIIPVHLYGLPAAMDAINEIARPLGIFVFEDAAQAHGATHNGKRTGVLGDAAAFS FYPTKNLGAMGDAGAVVTNDDALAGELRMLRNYGSSQKYVHEVAGVNSRLDELQAALLRT KLGRLDAWNEQRRALAARYSEGLRGVGDIRIPHVPSDSTHVYHLYVISTGRRAELSAHLT AQGIQTLVHYPIPPHVQGAYAELGLPADSLPLATAAANETLSLPIWPQMQPEQVDAVVAQ IRKFFA