Protein Info for GFF6844 in Variovorax sp. SCN45

Annotation: Putative PpiC-type peptidyl-prolyl cis-trans isomerase precursor associated with VreARI signaling system

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 304 signal peptide" amino acids 1 to 28 (28 residues), see Phobius details PF13145: Rotamase_2" amino acids 128 to 261 (134 residues), 65.5 bits, see alignment E=1.2e-21 PF13616: Rotamase_3" amino acids 147 to 247 (101 residues), 58 bits, see alignment E=2.1e-19 PF00639: Rotamase" amino acids 157 to 246 (90 residues), 65.1 bits, see alignment E=1.4e-21

Best Hits

KEGG orthology group: K01802, peptidylprolyl isomerase [EC: 5.2.1.8] (inferred from 65% identity to mms:mma_2374)

Predicted SEED Role

No annotation

Isozymes

Compare fitness of predicted isozymes for: 5.2.1.8

Use Curated BLAST to search for 5.2.1.8

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (304 amino acids)

>GFF6844 Putative PpiC-type peptidyl-prolyl cis-trans isomerase precursor associated with VreARI signaling system (Variovorax sp. SCN45)
MRRFKPSHAALVLLMSTAGMAGAQAPAAGNTVVARLGEATVAQDEIERLLQSLPEAERTA
IKADRTVLDNWLRQRLLSEAVLRDARAKGWADRADVKAKVEAATREIASRIVSTSYIESV
SQVPAGYPSDAEVKAAYEQGKTGYNLPAAYRVAQIYLATPDRDAAAVAKVREEAAKLARQ
ARTGDFAAVARASSQDKRSAERGGEVDTLPLARILPELRDTVARLKPGQVSEPVQAEAGF
HVVKLLDITPARTATLEEMKPQLQAALRQQRQQQLVQAYLAQVAPATNLSIDAAALDAAL
KKTN