Protein Info for GFF681 in Xanthobacter sp. DMC5

Annotation: L-lactate permease

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 568 transmembrane" amino acids 12 to 33 (22 residues), see Phobius details amino acids 39 to 60 (22 residues), see Phobius details amino acids 66 to 91 (26 residues), see Phobius details amino acids 116 to 149 (34 residues), see Phobius details amino acids 154 to 180 (27 residues), see Phobius details amino acids 197 to 215 (19 residues), see Phobius details amino acids 224 to 246 (23 residues), see Phobius details amino acids 252 to 269 (18 residues), see Phobius details amino acids 319 to 348 (30 residues), see Phobius details amino acids 385 to 406 (22 residues), see Phobius details amino acids 418 to 441 (24 residues), see Phobius details amino acids 458 to 476 (19 residues), see Phobius details amino acids 483 to 483 (1 residues), see Phobius details amino acids 545 to 566 (22 residues), see Phobius details TIGR00795: transporter, lactate permease (LctP) family" amino acids 6 to 561 (556 residues), 724 bits, see alignment E=6.3e-222 PF02652: Lactate_perm" amino acids 16 to 559 (544 residues), 699.7 bits, see alignment E=1.3e-214

Best Hits

KEGG orthology group: K00427, L-lactate permease (inferred from 75% identity to rva:Rvan_0888)

Predicted SEED Role

"L-lactate permease" in subsystem Lactate utilization

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (568 amino acids)

>GFF681 L-lactate permease (Xanthobacter sp. DMC5)
VGVWNQIYNPMGNMWLSSLGAAIPIIFFFVALTKLKLKGYVAGTITVLLALGVAILLYGM
PVQKALAAGVFGFFYGLWPIAWIIIGAVFLYKVSVETGQFEIIRRSILSVTEDQRLQLLL
VGFAFGAFLEGAAGFGAPVAITAALLVGLGFKPLYAAGLCLIANTAPVAFGAMGIPIIVA
GQVTGLDPFHIGQMAGRQLPFLSVLVPFWLILIMDGTRGVRETWPAILVAGGSFATVQFL
TANFVGPELPDITAALATLITLPLFLRFWQPRRIFRFETEAKTPGAKKPGLMDHGAAPAP
AGASVEPAVTYTAGQIVRAWSPFLILTVFVTIWSIPPFKALFAAGGALEGMVAHFSVPFL
HNMVVKLPPIVTAAKPFAADYKFDWLSATGTAIFLAAIVSVVFLGMKPSRAVSTFVSTIK
GLLIPIYSIGMVLAFAFIANYSGLSSTLGLALSETGPSFTFFSPFLGWLGVFLTGSDTSA
NALFASLQATTAHQIGVSDVLLVAVNTTGGVTGKMISPQSIAIACAAAGLIGRESDLFRF
TVKHSLALAAIVGIMTTIQAYLTPWMIP