Protein Info for GFF6784 in Variovorax sp. SCN45

Annotation: D-amino acid dehydrogenase (EC 1.4.99.6)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF01266: DAO
  • amino acids 15 to 413 (399 residues), 185.6 bits, E=3.9e-58

Best Hits

KEGG orthology group: K00285, D-amino-acid dehydrogenase [EC: 1.4.99.1] (inferred from 87% identity to vap:Vapar_3676)

MetaCyc: 43% identical to glyphosate oxidoreductase (Ochrobactrum sp. G-1)
RXN-17950 [EC: 1.5.3.23]

Predicted SEED Role

"D-amino acid dehydrogenase small subunit (EC 1.4.99.1)" in subsystem Pyruvate Alanine Serine Interconversions or Respiratory dehydrogenases 1 (EC 1.4.99.1)

MetaCyc Pathways

• glyphosate degradation I (1/1 steps found)

KEGG Metabolic Maps

• Nitrogen metabolism
• Phenylalanine metabolism

Isozymes

Compare fitness of predicted isozymes for: 1.4.99.1

Use Curated BLAST to search for 1.4.99.1 or 1.5.3.23

Protein Sequence (431 amino acids)

>GFF6784 D-amino acid dehydrogenase (EC 1.4.99.6) (Variovorax sp. SCN45)
MTVARSFSSAGTARHVVVIGAGAVGSATAIEALRAGLRVTVVEPGEPGGQHATSYGNAGW
LSSHSVVPPALPGAWRKVPGWLADPLGPLALRWRYLPRALPWLLRYLASGWTEARVQRTA
DALRTLLADAPTLHAQLATEAGVPQLIEQRGLLHAYRSRAEFEGDALGWRVRRRTGVQWE
EWPEEELRRREPDLDARYTLGVFVPEAGHCRNPGAYVAALARHALDAGAERIATRATGFR
IEGGRLRAVLTESGEIVCDGAAVCAGARSGPLAAAAGSAVPLESERGYHVVVEDAKVGPR
TPTMVADGKLIAHWMDGGLRAAGQVEIAGLEAAPDWRRAEILHAHLRSMFPSLARAEPGA
TSVRHWLGHRPSLPDGLPCIGPAAATSDVVLAFGHGHVGLCGSARTGRLAAQLLAGAAPE
IPLAPFDPARF