Protein Info for GFF6766 in Variovorax sp. SCN45

Annotation: MATE efflux family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 473 transmembrane" amino acids 25 to 46 (22 residues), see Phobius details amino acids 58 to 83 (26 residues), see Phobius details amino acids 103 to 126 (24 residues), see Phobius details amino acids 146 to 167 (22 residues), see Phobius details amino acids 179 to 199 (21 residues), see Phobius details amino acids 205 to 228 (24 residues), see Phobius details amino acids 252 to 276 (25 residues), see Phobius details amino acids 296 to 318 (23 residues), see Phobius details amino acids 329 to 350 (22 residues), see Phobius details amino acids 370 to 391 (22 residues), see Phobius details amino acids 398 to 420 (23 residues), see Phobius details amino acids 431 to 454 (24 residues), see Phobius details TIGR00797: MATE efflux family protein" amino acids 32 to 413 (382 residues), 163.8 bits, see alignment E=3e-52 PF01554: MatE" amino acids 32 to 192 (161 residues), 79.2 bits, see alignment E=1.5e-26 amino acids 262 to 411 (150 residues), 68.8 bits, see alignment E=2.3e-23

Best Hits

KEGG orthology group: None (inferred from 94% identity to vap:Vapar_3694)

Predicted SEED Role

"Na+ driven multidrug efflux pump"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (473 amino acids)

>GFF6766 MATE efflux family protein (Variovorax sp. SCN45)
MTAPGNTAELDPRTRRLLEAPIVPTLLRLAAPNVLVMVAQASVGLIETYFVGKLGTDALA
GMALVFPIVMLMQMTSSGAMGGGIASSIARALGARRRADADALVWHAIVIALGFGLCFTL
ALLLGGRWLYGIMGGTGPALEAALTYSHWVFSGAVLVWLFNSLSAIIRGTGNMSVPANVT
VVGVVFLIPASPLLIFGIGPLPGMGIAGGAMALLLYYLLGSIALIVYLRSPRSLLRPTLA
ALKLRWPLFRDILRIGLVGAVSTVATNLSIGIATALTGHFGSGALAGYGTASRLEYLLVP
LVFGLGAPLVAMVGTCMGAGQRERALRATWAGAALAFALTETIGLAAALFPRPWLLLFGN
DPAMLETGAHYLRVVGPLYGFFGVGLVLYFASQGAGRLLWPVLGNIARLAVAGTGGWLAL
RWGGGLTGVFAAQGVALVVYGIVIASAIAGGAWFGRVGWPRTTNGLLRRVAQA