Protein Info for GFF667 in Hydrogenophaga sp. GW460-11-11-14-LB1
Annotation: Peptide methionine sulfoxide reductase MsrB (EC 1.8.4.12)
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 54% identical to MSRB_AGRFC: Peptide methionine sulfoxide reductase MsrB (msrB) from Agrobacterium fabrum (strain C58 / ATCC 33970)
KEGG orthology group: K07305, peptide-methionine (R)-S-oxide reductase [EC: 1.8.4.12] (inferred from 74% identity to del:DelCs14_3653)Predicted SEED Role
"Peptide methionine sulfoxide reductase MsrB (EC 1.8.4.12)" (EC 1.8.4.12)
Isozymes
Compare fitness of predicted isozymes for: 1.8.4.12
Use Curated BLAST to search for 1.8.4.12
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (157 amino acids)
>GFF667 Peptide methionine sulfoxide reductase MsrB (EC 1.8.4.12) (Hydrogenophaga sp. GW460-11-11-14-LB1) MTTRRHLLLTTAGLWPLWVWAAAPGETFEVRYSDAEWRQRLTPQRYAVLRKEDTELPYSS PLNKEHRVGTFACAGCDLPLFSSKTKFDSGTGWPSFWKPLDNAVGTRTDKAFGMVRTEVH CRRCGGHLGHVFDDGPKPTGLRYCMNGLSLSFTPQAT