Protein Info for GFF6658 in Variovorax sp. SCN45

Annotation: Multidrug efflux system MdtABC-TolC, inner-membrane proton/drug antiporter MdtC (RND type)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1096 transmembrane" amino acids 12 to 33 (22 residues), see Phobius details amino acids 335 to 353 (19 residues), see Phobius details amino acids 360 to 381 (22 residues), see Phobius details amino acids 387 to 410 (24 residues), see Phobius details amino acids 431 to 451 (21 residues), see Phobius details amino acids 463 to 490 (28 residues), see Phobius details amino acids 532 to 551 (20 residues), see Phobius details amino acids 922 to 940 (19 residues), see Phobius details amino acids 947 to 967 (21 residues), see Phobius details amino acids 973 to 998 (26 residues), see Phobius details amino acids 1020 to 1041 (22 residues), see Phobius details amino acids 1053 to 1077 (25 residues), see Phobius details PF00873: ACR_tran" amino acids 7 to 806 (800 residues), 734 bits, see alignment E=2.7e-224 amino acids 837 to 1077 (241 residues), 269.9 bits, see alignment E=4.1e-84

Best Hits

KEGG orthology group: K07789, RND superfamily, multidrug transport protein MdtC (inferred from 58% identity to bpy:Bphyt_1575)

Predicted SEED Role

"Cobalt-zinc-cadmium resistance protein CzcA; Cation efflux system protein CusA"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1096 amino acids)

>GFF6658 Multidrug efflux system MdtABC-TolC, inner-membrane proton/drug antiporter MdtC (RND type) (Variovorax sp. SCN45)
MNLSLPFVRRPIGTVLLTIGVALAGIAAFFVLPVSPLPQVDYPVISVSAAIPGASPETMA
TSVATPLERHLGTIAGVNEMTSTSSVGTSRVTLQFDLSRDINGAAREVQAAISASRVDLP
ATLRSNPTYRKANPASSPVIILALTSKTKTPGQIYDAVSNIVSQRLSQVDGVGDVEIGGG
SLPAVRIELLPFALSRYGISTDDVRAAIQASNANRPKGMVQGEGRKLQIYTQTPALRASD
YAPMVIAWRNGAAVRLQDVAEVLDGVEDTRTLGLFNGEPAIIVLITRQPSANIIETVDSV
RALLPELQAQLPPDVTLQVASDSTNSIRGSLREVEFTLVISVILVVLVVSLFLRSARATI
VPAVATVAALLGTFGVMYLLGFSLNNLSLMALTVATGFVVDDAIVVLENTSRHIESGMTR
MKAALLGAKEVGFTVLSISVSLVAVFIPLLFMGGQVGRLFREFAVTLSAAVMISLVISLT
TTPMMCAWMLKPGGEHDKNKPQGRFGRMAARSYDWVLKRYENSLDWALDSKGLVMLILVA
VVGLNVYLFSAAPKGFFPQQDSGQLNGGLRADQSISSKAMAAKLREVVDIIRADEAVDTV
VGFTGGSRAGGGFMFVNLKPASQRKDSGLAVIARLRPKLNAVAGLRVFLGTVQDVRSGGR
SSNSTYQYTLKSDNLADLRTWASKLADEMKLQPVLTDIDTDQTENGVETMANVDKNTANR
LGITSTAVDNALYNAFGQRQVATIYTELNQYHVVMEWAPRYTLSPNALSDVYVPATKTTV
VAGQAVTTQVAAPTTTANSALSASKTAAGSTAASSSSTAVPVSANPALRNASSGNVLSNT
ATSLVPLSAVAKFYENSVATSVSHQDGELATTVSFNLVEGANLGDAREAIAKAEANIAMP
TNVRGAFAGTAASAQQSQSQQAMLILAALVVIYIVLGILYESLVHPITVLSTLPSAGVGA
VLALLMFRMEFSIIALIGVFLLIGIVKKNAILIIDFALEAERSRGLSPLEAVREACLLRF
RPILMTTMAAALGALPLAIGFGEGAELRRPLGVAIIGGLIASQMLTLLTTPVVYLLLDKL
RRRGANEHELSRATTA