Protein Info for GFF6357 in Variovorax sp. SCN45

Annotation: T6SS forkhead associated domain protein ImpI/VasC

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 628 PF00498: FHA" amino acids 27 to 95 (69 residues), 39 bits, see alignment E=8.8e-14 TIGR03354: type VI secretion system FHA domain protein" amino acids 335 to 618 (284 residues), 169.3 bits, see alignment E=1.2e-53 PF20232: T6SS_FHA_C" amino acids 438 to 617 (180 residues), 176.8 bits, see alignment E=3.8e-56

Best Hits

KEGG orthology group: K07169, FHA domain-containing protein (inferred from 72% identity to vap:Vapar_0208)

Predicted SEED Role

"Uncharacterized protein ImpI/VasC"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (628 amino acids)

>GFF6357 T6SS forkhead associated domain protein ImpI/VasC (Variovorax sp. SCN45)
MRWTVIEHAGKPVATGPSALLAAPGGTIGRSPDNHLVLPDEQRQISRLQATVRFDEDGAA
VLRNMSAVLPISVNGRTLVHEQEARVADGDRVEIGSYVLEAASALRAAPAVVVAPPPPQA
PPLQAPSMPAPQPFTQAPVSSAPIDALLPASSGADVFSDLFGEGTLPIGDTQPTVAMPPP
VPRAPVQSPPPAVPPVQVHVPAPPPPPMPAQAPPKAIPASSQIPSAEDWDAILANAPRRI
DSTPAPMPDPMAHEPFELPSQARRNPVDPLAEMNPQSAHDMSDIALKRGVDPLSFFAADD
SAHSPLSDPRPTALTQHDAGLPGDVHPALDLLQNNKPAVPGYSHSNHAREVTAQFRPPLP
AAPVPVPPPPLAPAPVVAVEKIEEPPPPPPPPPPAPPPVVAAVPVAPAVVATSPSPSPSP
ATSTTDSSSEALFKAFLEGAGVPEIAGQQPLDIEAMQRLGRIMRAFTDGTIELLSSRAML
KREVRAEITMIVDEENNPFKILPNGRAVLMQMFGARMPGFLPPEAAVHDALGDLQSHQLG
MVAGMRAALLTLLQRFDPAALSSNTPHDGGIGEKLLPGGREARLWRELQQLHTETTAAVE
DDFQAVFGRAFQQAYDKEMERLKEARRA