Protein Info for GFF631 in Variovorax sp. SCN45

Annotation: Formamidase (EC 3.5.1.49)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF03069: FmdA_AmdA
  • amino acids 7 to 384 (378 residues), 613.3 bits, E=7.8e-189

Best Hits

Swiss-Prot: 71% identical to FMDA_METME: Formamidase (fmdA) from Methylophilus methylotrophus

KEGG orthology group: K01455, formamidase [EC: 3.5.1.49] (inferred from 99% identity to vpe:Varpa_3561)

MetaCyc: 57% identical to formamidase subunit (Paracoccidioides brasiliensis)
Formamidase. [EC: 3.5.1.49]

Predicted SEED Role

"Formamidase (EC 3.5.1.49)" (EC 3.5.1.49)

MetaCyc Pathways

• cyanide detoxification II (1/2 steps found)

KEGG Metabolic Maps

• Glyoxylate and dicarboxylate metabolism
• Nitrogen metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.5.1.49

Protein Sequence (410 amino acids)

>GFF631 Formamidase (EC 3.5.1.49) (Variovorax sp. SCN45)
MTDTLIKVDLTKPPTENENIHNRWHPDIPMACWVNPGDDFILETFDWTGGFIKNNDSADD
VRDIDLSTVHYLSGPVGVKGAEPGDLLVVDLLDIGAKQDSLWGFNGFFSKKNGGGFLTDH
FPEAQKSIWDFKGMFTSSRHIPGVNFAGLIHPGLIGCLPDKPMLDMWNEREKALIATDPD
RVPGLANPPFAGTAHMGKMTGEARAKAAAEGARTVPPREHGGNCDIKDLSRGSKVFFPVY
VDGAGLSVGDLHFSQGDGEITFCGAIEMAGWVHMKVTLIKGGMAKYGIKNPIFKPSPITP
QYNDYLIFEGISVDESGKQHYLDVNVAYRQACLNAIEYLKKFGYSGAQAYSILGTAPVQG
HISGVVDVPNSCATLWLPTGIFDFDINPNASGPVKFIDGSIDMPLSPDLR