Protein Info for GFF6202 in Variovorax sp. SCN45

Annotation: Unknown substrate:proton symporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 496 transmembrane" amino acids 22 to 44 (23 residues), see Phobius details amino acids 55 to 76 (22 residues), see Phobius details amino acids 85 to 105 (21 residues), see Phobius details amino acids 112 to 133 (22 residues), see Phobius details amino acids 140 to 165 (26 residues), see Phobius details amino acids 215 to 233 (19 residues), see Phobius details amino acids 240 to 263 (24 residues), see Phobius details amino acids 289 to 312 (24 residues), see Phobius details amino acids 366 to 387 (22 residues), see Phobius details amino acids 394 to 415 (22 residues), see Phobius details amino acids 427 to 446 (20 residues), see Phobius details amino acids 453 to 476 (24 residues), see Phobius details TIGR00801: uracil-xanthine permease" amino acids 16 to 474 (459 residues), 378.1 bits, see alignment E=5.7e-117 PF00860: Xan_ur_permease" amino acids 21 to 170 (150 residues), 121.1 bits, see alignment E=2.4e-39 amino acids 209 to 441 (233 residues), 230.5 bits, see alignment E=1.5e-72

Best Hits

KEGG orthology group: K03458, nucleobase:cation symporter-2, NCS2 family (inferred from 97% identity to vap:Vapar_3941)

Predicted SEED Role

"Xanthine permease" in subsystem Purine Utilization

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (496 amino acids)

>GFF6202 Unknown substrate:proton symporter (Variovorax sp. SCN45)
MTADATLSQVHPVDQRLPSGKLAALGLQHVLVMYAGAVAVPLIVGRALKLTPDEVALLIS
ADLFCCGIATLIQALGATQWFGIKLPVMMGVTFASVAPMVAIANANPGQNGAQLLFGSII
GAGVVSILIAPLVSRMLRFFPPVVTGTIIAVIGISLMRVGINWIFGNPVGPTAPALVDPV
YAKWLAEVTSPGSSIPAVPKGFAIMPTVPNPKYADLSGFGVATLVLVSILLIVKYAKGFV
ANISVLLGIVIGAVVASITGLMTYEKVGKAAWVDIVLPFHFGMPQFDPILILTMTLIMIV
VMIESTGMFLALGEMTGRKIDQKDLARGLRTDGLGTLIGGVFNTFPYTSFSQNVGLVAVT
GIRSRYVCVAGGVILIVLGLLPKMAALVESLPTVVLGGAGLVMFGMVAATGIRILSGVDF
KNNRHNAMIVAVSIGIGMIPLIAPNFKQWMPHAIHSLIESGILLASIAAVLLNLFLNGAK
HDEQAVIAAAKQAEAH