Protein Info for GFF6183 in Variovorax sp. SCN45

Annotation: Phosphoserine aminotransferase (EC 2.6.1.52)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

Best Hits

Swiss-Prot: 75% identical to SERC_POLSJ: Phosphoserine aminotransferase (serC) from Polaromonas sp. (strain JS666 / ATCC BAA-500)

KEGG orthology group: K00831, phosphoserine aminotransferase [EC: 2.6.1.52] (inferred from 92% identity to vpe:Varpa_1780)

MetaCyc: 48% identical to phosphoserine aminotransferase (Arabidopsis thaliana col)
Phosphoserine transaminase. [EC: 2.6.1.52]

Predicted SEED Role

"Phosphoserine aminotransferase (EC 2.6.1.52)" in subsystem Glycine and Serine Utilization or Pyridoxin (Vitamin B6) Biosynthesis or Serine Biosynthesis (EC 2.6.1.52)

MetaCyc Pathways

superpathway of sulfate assimilation and cysteine biosynthesis (9/9 steps found)
superpathway of L-serine and glycine biosynthesis I (4/4 steps found)
pyridoxal 5'-phosphate biosynthesis I (6/7 steps found)
L-serine biosynthesis I (3/3 steps found)
L-cysteine biosynthesis IX (Trichomonas vaginalis) (2/3 steps found)
superpathway of pyridoxal 5'-phosphate biosynthesis and salvage (7/12 steps found)

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.6.1.52

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (376 amino acids)

>GFF6183 Phosphoserine aminotransferase (EC 2.6.1.52) (Variovorax sp. SCN45)
VTQQQTPAGKRPYNFSAGPAAMPEAVLQRAASEMLDWHGSGMSVMEMSHRGKEFGSICTQ
AEADIRTLLAVPSNFHVLFMQGGGLGENAIVPLNLSRGKTADFVITGSWSAKSHKEAQRY
CTARVIASNADDQHTRLPDPATWQLSKDASYVHVCSNETINGIEFQQLPDLAALGSNAPL
VIDFSSHVASRSVDWSRVGLAFGGAQKNLGPAGLTIVVVRDDLLGHALEICPSAFNYKTV
ADNNSMYNTPPTWGIYMAGLTFQWLLQQKEGEFTGVAAMEQRNIAKAKLLYDFIDGSDFY
ANRIDPGCRSRMNVPFFLADEGRNEAFLAGAREAGLLQLKGHKSVGGMRASIYNAMPLEG
VQALVGYMREFERSHA