Protein Info for GFF6171 in Variovorax sp. SCN45

Annotation: Na(+) H(+) antiporter subunit D

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 572 transmembrane" amino acids 18 to 37 (20 residues), see Phobius details amino acids 47 to 67 (21 residues), see Phobius details amino acids 91 to 118 (28 residues), see Phobius details amino acids 127 to 145 (19 residues), see Phobius details amino acids 151 to 169 (19 residues), see Phobius details amino acids 181 to 205 (25 residues), see Phobius details amino acids 227 to 252 (26 residues), see Phobius details amino acids 259 to 280 (22 residues), see Phobius details amino acids 296 to 317 (22 residues), see Phobius details amino acids 325 to 343 (19 residues), see Phobius details amino acids 349 to 370 (22 residues), see Phobius details amino acids 421 to 441 (21 residues), see Phobius details amino acids 462 to 485 (24 residues), see Phobius details amino acids 506 to 526 (21 residues), see Phobius details PF00361: Proton_antipo_M" amino acids 148 to 375 (228 residues), 86.9 bits, see alignment E=7.1e-29

Best Hits

KEGG orthology group: K05561, multicomponent K+:H+ antiporter subunit D (inferred from 92% identity to vpe:Varpa_1765)

Predicted SEED Role

"Na(+) H(+) antiporter subunit D" in subsystem Sodium Hydrogen Antiporter

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (572 amino acids)

>GFF6171 Na(+) H(+) antiporter subunit D (Variovorax sp. SCN45)
MTEIFHLLDQLLEFSMPHLVAVPILVPMLTAALMLLLGENRRRTKSFLSVVSGLVGLLAA
LALLRWVNAPETGGGPGSIGVYLPGNWRAPFGIVLVADRLSTMMVALTGVVAFAASIYST
SRWDRAGVHFHPLLQLQLMGLNGAFLTGDLFNLFVFFEVMLAASYGLLLHGSGRLRVQAG
LHYIAINLAASSLFLIGAAILYGVTGTLNMADLGMRIAELAPGDRGLVHAATAILFTAFF
AKAGAWPLNFWLVPAYSSAVSPVGAVFALLTKLGVYTVLRLWTVLFAPDTGASAAFGQPV
LVGAGIATLFVAAFGIVGTQRLSNLAGFSVLISAGTLLAAVGLGQPAVWAGALFYMLSST
LAVSAFFLLIDMIERWRNAGMSVAPHEAAGTAPFLAEDLSALSDVNLDDDAQALYGRAIP
AGVAFLGLSFLICTLLLTGLPPLSGFVGKFAMLTGLMGVNGAIGAAGWTFLVLLIASGFL
ALIALTRTGIRHFWTQPHGNLPSLPALEVLPVAGLIATCIALTVWAEPVLRHAMATAEGL
RTPTAYRAAVMQARQVPNPVPAAKAEAKGATP