Protein Info for GFF6144 in Variovorax sp. SCN45

Annotation: 2-aminoethylphosphonate ABC transporter substrate-binding protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 346 signal peptide" amino acids 1 to 30 (30 residues), see Phobius details TIGR03261: putative 2-aminoethylphosphonate ABC transporter, periplasmic 2-aminoethylphosphonate-binding protein" amino acids 14 to 344 (331 residues), 536.1 bits, see alignment E=1.5e-165 PF13531: SBP_bac_11" amino acids 35 to 288 (254 residues), 61.5 bits, see alignment E=2.1e-20 PF01547: SBP_bac_1" amino acids 40 to 286 (247 residues), 89.8 bits, see alignment E=7e-29 PF13416: SBP_bac_8" amino acids 50 to 296 (247 residues), 80.9 bits, see alignment E=2.9e-26 PF13343: SBP_bac_6" amino acids 82 to 313 (232 residues), 89.2 bits, see alignment E=6.1e-29

Best Hits

KEGG orthology group: K02012, iron(III) transport system substrate-binding protein (inferred from 93% identity to vpe:Varpa_1735)

Predicted SEED Role

"Ferric iron ABC transporter, iron-binding protein" in subsystem Campylobacter Iron Metabolism or Iron acquisition in Vibrio or Transport of Iron

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (346 amino acids)

>GFF6144 2-aminoethylphosphonate ABC transporter substrate-binding protein (Variovorax sp. SCN45)
MTMKQSTRRLTAVLCAAALGLAASGAAWAQKTSLLVYTALETDAMKLYKDAFEKANPDIE
VKWVRDSTGIVTAKLLAEKANPQADVVAGLAASSLALLQQEGMLLPYEPKGFKELNPAYS
DAARPPAWVGMDVWAATICFNRVEAKKLNLPKPETWQDLAKPVYKGTITMPHPASSGTGY
LDVSSWLQNMGDAEGWKYMDALHQNIAQYVHSGSKPCKQAGAGEFPIGISFEFRAHQVKK
SGAPVDLIFPKEGLGWDIEATSVMKTSKKPDQAKRFADWMASKEANQITSTWWAVVAYPG
VASKLEGIPDNYEKLLAKNDINWAAKNRERILAEWSKRYEGKAEPK