Protein Info for GFF602 in Sphingobium sp. HT1-2

Annotation: Inner membrane protein translocase and chaperone YidC, long form

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 568 transmembrane" amino acids 7 to 24 (18 residues), see Phobius details amino acids 347 to 353 (7 residues), see Phobius details amino acids 359 to 378 (20 residues), see Phobius details amino acids 422 to 442 (21 residues), see Phobius details amino acids 482 to 502 (21 residues), see Phobius details amino acids 518 to 541 (24 residues), see Phobius details TIGR03593: membrane protein insertase, YidC/Oxa1 family, N-terminal domain" amino acids 5 to 357 (353 residues), 287.3 bits, see alignment E=2.6e-89 PF14849: YidC_periplas" amino acids 74 to 347 (274 residues), 254.7 bits, see alignment E=1.7e-79 TIGR03592: membrane protein insertase, YidC/Oxa1 family" amino acids 358 to 555 (198 residues), 225.2 bits, see alignment E=7.3e-71 PF02096: 60KD_IMP" amino acids 359 to 556 (198 residues), 204.1 bits, see alignment E=1.4e-64

Best Hits

Swiss-Prot: 46% identical to YIDC_METEP: Membrane protein insertase YidC (yidC) from Methylobacterium extorquens (strain PA1)

KEGG orthology group: K03217, preprotein translocase subunit YidC (inferred from 89% identity to sjp:SJA_C1-07590)

Predicted SEED Role

"Inner membrane protein translocase component YidC, long form"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (568 amino acids)

>GFF602 Inner membrane protein translocase and chaperone YidC, long form (Sphingobium sp. HT1-2)
VDDKKNIILAVLLTAAILFGWPYISEHFFPAANPPATKIEGGKTTPLTPAGEAPAQDAST
AIRDRALVLKETPRVAIRTPKIIGSINLKGARIDDIVLPTYKETIAKDSPAIRLYSPSGT
KDAYFAGFGWQGEGIKTPDANTVWTASGTELTPTSPVTLSWNNGAGQNFEIRYSIDENYM
ISAAQKVSNSGTGAIAVKSYGYVSRAAPSADPDTWTIHVGPMGVFNGAANYDVNYKDLEK
GPASQSFQSTGGWIGFTDKYWLSALIPDQKDAFTGQMRKGAGTQFQTDIALAPVMLAPGK
AMTQTNRLFVGAKEVKTLQAYERAGVPLFDRAIDWGWFYWFEQPIFALLHWLFETLGNFG
VAIICLTFCVRALMFPVAQRQFASMAAMRAVQPKMKALQEKYKDDKQQLQQKMMELYKQE
KVNPLAGCLPIFIQIPIFFALYKVLQLTIEMRHQPFVLWIKDLSAPDPLHILNLFGLLPF
TPPSFLAIGVLALLLGISMWLQFKLNPAQMDPMQQQVFAIMPWMMMFIMAPFAAGLLVYW
ITNNCLSMAQQWWLYKRHPVLNTATATK