Protein Info for GFF595 in Xanthobacter sp. DMC5

Annotation: DNA polymerase IV

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00817: IMS
  • amino acids 47 to 193 (147 residues), 155.3 bits, E=1.7e-49
• PF11799: IMS_C
  • amino acids 280 to 382 (103 residues), 89.3 bits, E=3.4e-29

Best Hits

Swiss-Prot: 65% identical to DPO41_RHIME: DNA polymerase IV 1 (dinB1) from Rhizobium meliloti (strain 1021)

KEGG orthology group: K02346, DNA polymerase IV [EC: 2.7.7.7] (inferred from 86% identity to xau:Xaut_3857)

Predicted SEED Role

"DNA polymerase IV (EC 2.7.7.7)" in subsystem DNA repair, bacterial (EC 2.7.7.7)

KEGG Metabolic Maps

• Purine metabolism
• Pyrimidine metabolism

Isozymes

Compare fitness of predicted isozymes for: 2.7.7.7

Use Curated BLAST to search for 2.7.7.7

Protein Sequence (433 amino acids)

>GFF595 DNA polymerase IV (Xanthobacter sp. DMC5)
MTAPGLCRDCLSDVPALDGRRGARCPACGSPRVVRHGELHSLSVAHVDCDAFYAAVEKRD
NPDLAHVPLIIGGGKRGVVSTACYIARIHGVRSAMPMFKALALCPDAVVLKPNMEKYVKV
GREVRARMKALTPLVEPLSIDEAFLDLSGTEALHQASPARTLARFARDVEREVGITVSVG
LAANKFLAKIASDLDKPRGFSVIGQSEAAEFLAPRPVTFIWGVGAAFGGKLARDGFSTIG
DLQRAEPADLARRYGAEGLRLSRLAFGLDTRKVEPEREAKSVSAETTFDRDIGALRPLEQ
TLYALSEEVSERLKRAGIAGRSVTLKLKSADFRLRTRSRTLDAPTCLAARINAAAHELLV
KETDGTLFRLIGVGVSDLGPIADADPADLVDTTSQRLKATETAMDALRAKFGRGAVSRGI
LLDATTDRRNRKK