Protein Info for GFF5850 in Variovorax sp. SCN45

Annotation: Aldehyde dehydrogenase (EC 1.2.1.3); Probable coniferyl aldehyde dehydrogenase (EC 1.2.1.68)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00171: Aldedh
  • amino acids 3 to 435 (433 residues), 300.8 bits, E=1.5e-93

Best Hits

Swiss-Prot: 52% identical to CALB_PSEAE: Probable coniferyl aldehyde dehydrogenase (calB) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)

KEGG orthology group: K00154, coniferyl-aldehyde dehydrogenase [EC: 1.2.1.68] (inferred from 87% identity to vpe:Varpa_3494)

Predicted SEED Role

"Aldehyde dehydrogenase (EC 1.2.1.3); Probable coniferyl aldehyde dehydrogenase (EC 1.2.1.68)" (EC 1.2.1.3, EC 1.2.1.68)

MetaCyc Pathways

• ethanol degradation II (3/3 steps found)
• ethanol degradation IV (3/3 steps found)
• superpathway of NAD/NADP - NADH/NADPH interconversion (yeast) (6/8 steps found)
• phytol degradation (3/4 steps found)
• ethanol degradation III (2/3 steps found)
• hypotaurine degradation (2/3 steps found)
• mitochondrial NADPH production (yeast) (3/5 steps found)
• octane oxidation (3/5 steps found)
• fatty acid α-oxidation I (plants) (2/4 steps found)
• putrescine degradation III (2/4 steps found)
• histamine degradation (1/3 steps found)
• 3-methyl-branched fatty acid α-oxidation (3/6 steps found)
• L-tryptophan degradation X (mammalian, via tryptamine) (1/4 steps found)
• ferulate and sinapate biosynthesis (1/4 steps found)
• limonene degradation IV (anaerobic) (3/7 steps found)
• serotonin degradation (3/7 steps found)
• dopamine degradation (1/5 steps found)
• ceramide degradation by α-oxidation (2/7 steps found)
• sphingosine and sphingosine-1-phosphate metabolism (4/10 steps found)
• alkane oxidation (1/6 steps found)
• aromatic biogenic amine degradation (bacteria) (1/8 steps found)
• noradrenaline and adrenaline degradation (4/13 steps found)
• ceramide and sphingolipid recycling and degradation (yeast) (4/16 steps found)

KEGG Metabolic Maps

• 1,2-Dichloroethane degradation
• 3-Chloroacrylic acid degradation
• Arginine and proline metabolism
• Ascorbate and aldarate metabolism
• Butanoate metabolism
• Fatty acid metabolism
• Glycerolipid metabolism
• Glycolysis / Gluconeogenesis
• Histidine metabolism
• Limonene and pinene degradation
• Lysine degradation
• Phenylpropanoid biosynthesis
• Propanoate metabolism
• Pyruvate metabolism
• Tryptophan metabolism
• Urea cycle and metabolism of amino groups
• Valine, leucine and isoleucine degradation
• beta-Alanine metabolism

Isozymes

Compare fitness of predicted isozymes for: 1.2.1.3

Use Curated BLAST to search for 1.2.1.3 or 1.2.1.68

Protein Sequence (466 amino acids)

>GFF5850 Aldehyde dehydrogenase (EC 1.2.1.3); Probable coniferyl aldehyde dehydrogenase (EC 1.2.1.68) (Variovorax sp. SCN45)
MTQDMRQTFDAMRAASLRGQTQPWPERADRLRRLRALVKDNREQIAAAISADFHNRAFQE
TELAEVFPALEGIAHALRHGRHWMRVRRRSTGLWFKPASSKIMPQPLGVVGIVVPWNYPL
YLAVGPMTAALAAGNRVMVKQSEYTPRFAELFAALVSKAFAPDEIAVVNGDAEAAREFSA
LPFDHLLFTGSTAVGHHVMRAASDNLTPVTLELGGKSPAIIGPDANFDKAVERILVGKTL
NAGQTCIAPDYVLVPEGQQQRFAESARRVFASMYPDLGSGNTDYTSIVSPRHFARLQELA
AAAQQEGASAVPLSDTAPDAATRRFPPVLLTGVNDGMRVMREEIFGPLLPVLPYGGIDEA
IAYVNAHPRPLALYLFEKNGATIDRVMSQTVSGGVSINDTLLHIAQDDLPFGGVGASGMG
AYHGEYGFETFSKLKPIFRQSAFNGAGLFRPPYGKTFARMMKLLVR