Protein Info for GFF583 in Xanthobacter sp. DMC5

Annotation: DNA polymerase III subunit alpha

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1155 TIGR00594: DNA polymerase III, alpha subunit" amino acids 7 to 1031 (1025 residues), 1194 bits, see alignment E=0 PF02811: PHP" amino acids 9 to 181 (173 residues), 134.3 bits, see alignment E=1.1e-42 PF07733: DNA_pol3_alpha" amino acids 307 to 573 (267 residues), 344.2 bits, see alignment E=1.1e-106 PF17657: DNA_pol3_finger" amino acids 576 to 736 (161 residues), 216.7 bits, see alignment E=2.5e-68 PF14579: HHH_6" amino acids 811 to 898 (88 residues), 95.9 bits, see alignment 2.6e-31

Best Hits

KEGG orthology group: K02337, DNA polymerase III subunit alpha [EC: 2.7.7.7] (inferred from 82% identity to azc:AZC_1691)

Predicted SEED Role

"DNA polymerase III alpha subunit (EC 2.7.7.7)" in subsystem DNA-replication (EC 2.7.7.7)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.7.7.7

Use Curated BLAST to search for 2.7.7.7

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1155 amino acids)

>GFF583 DNA polymerase III subunit alpha (Xanthobacter sp. DMC5)
MSTDPGFIHLHVHSSYSLLEGALSVGKLADLAKADYQPAIALTDTGNLFGALEFSEKMSG
SGIQPIPGVSLALDLPEPAGPRGGLRPRKPRVVLLAKDDAGWRNLMRLVSRSFLETASED
EPRILPEWLAEANDGLICLTGGPSGPLDRAIVGGHPEMAADRLDLLTSLFGDRLYVEVQR
HGADPERLAEPALLDLAYTKGVPLVAANEPFFAAKSDYEAHDGLLAIAEGRLLSEGDRRR
LTAEHRFKTRAEMLELFADLPEATANTVEIAKRCAYRVRTVKPILPRFTTADEKAEGSDP
LEAEAAELKRQAEEGLAARLAKHGPAPGLDEAAYHDRLAYEVSVITKMKFPGYFLIVSDF
IKWAKAHDIPVGPGRGSGAGSLVAYSLQITDLDPLRFGLLFERFLNPDRVSMPDFDVDFC
QERRDEVIRYVQERYGRAQVAQIITFGTLQARGVLRDVGRVLEMPYGQVDKLCKLVPQNP
ANPVTLKQAIEDEPRLQAARDQEEVVKRAFDIAVKLEGLNRHASTHAAGIVIGDRQLHEL
VPLYRDPKSDMPVTQYNMKWVEQAGLVKFDFLGLKTLTTIEKAVKLVHQRGIELDISKIP
LDDAKTYHMLGKGETVGVFQVESAGMRRALVDMKADRIEDIVALVALYRPGPMANIPVYC
DCKHGRATPDYLHPMLEPYLKETFGVIIYQEQVMQIAQAMAGYSLGEADLLRRAMGKKIR
AEMEKQRERFVSGAAGRGIEKAQADTIFDLLAKFADYGFNKSHAAAYALVAYQTAWLKAN
YPTEFLAASMTLDKGNTDKLAEFRQEAQRLGIEVVPPNINLSAREFGVKDGKIIYAMAAI
KGVGEAAVEALVAARGDRPFRSFADFATRLPVKLVNKRTLESLMAAGCFDVLEKNRARAF
AAIEPIVAEAQRVEANAQSGQNDMFGSGPAAAASLPIPEASPWLPSERLQKEYDSIGFFL
TGHPLDDYAEALKKMRVQSFADFSRAVRSGAAAGRLAATVVSKQERRTKSGTRMGIVGLS
DPSGHYEAVIFSEGLAHYRDLLEPGTPLLMMVAAEMNGEDVRVRINSCEKLDPVTAKHQK
GLRIFLRSPEPIEGIARRLSDGKSGEKGAGEVSLILLVDDAHAEVEVSLPGKYSVSPQIA
GAIKAIPGVVAVEAA