Protein Info for GFF579 in Variovorax sp. SCN45

Annotation: DNA polymerase III alpha subunit (EC 2.7.7.7)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1172 TIGR00594: DNA polymerase III, alpha subunit" amino acids 2 to 1035 (1034 residues), 1165.6 bits, see alignment E=0 PF02811: PHP" amino acids 4 to 172 (169 residues), 138 bits, see alignment E=9.6e-44 PF07733: DNA_pol3_alpha" amino acids 299 to 578 (280 residues), 335.7 bits, see alignment E=5.7e-104 PF17657: DNA_pol3_finger" amino acids 581 to 744 (164 residues), 209.6 bits, see alignment E=4.8e-66 PF14579: HHH_6" amino acids 821 to 911 (91 residues), 98.9 bits, see alignment 4.1e-32 PF01336: tRNA_anti-codon" amino acids 1003 to 1075 (73 residues), 29.3 bits, see alignment 1.7e-10

Best Hits

KEGG orthology group: K02337, DNA polymerase III subunit alpha [EC: 2.7.7.7] (inferred from 76% identity to ajs:Ajs_1830)

Predicted SEED Role

"DNA polymerase III alpha subunit (EC 2.7.7.7)" in subsystem DNA-replication (EC 2.7.7.7)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.7.7.7

Use Curated BLAST to search for 2.7.7.7

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1172 amino acids)

>GFF579 DNA polymerase III alpha subunit (EC 2.7.7.7) (Variovorax sp. SCN45)
MFVHLRLHTEFSVVDGTNRIDEAIKAAAADKQPALAITDLNNLFGAVKFYKQGRGKGVKP
VIGAEIFIDGLGKEPGALTRIVLLVQSMEGYLNLSELLARAWTQNVARGQSQAACKLEWV
QELSGGLIALSGAQAGPLGQPLLQGQGERAAELALQLAGIFPHRFYIELQRAGRPEDEPH
VIAAVQLAARLKLPVVATHPVQFAAREDYEAHEARVCISEGEILGNPRRVRRFTEEQYFK
STAEMQALFADVPSALANTVEIAKRCNLTLVLGKPQLPDFPTPFISEGVRMPIDDFFRQE
SFEGLEMRLRHLYPDEAKREAQRARYVERLEFEINTILNMGFPGYFLIVGDFIKWAKENG
CPVGPGRGSGAGSLVAYALKITDLDPLEYKLLFERFLNPERVSMPDFDIDFCQGNRDRVI
DYVKDKYGRNAVSQIATFGTMAARAAIRDVGRVLDMSYMFCDGISKLIPNKPGMSVTLQY
PPEKKIEGDKNNYAIEMEPQLAERIEKEEEVRMLVELAQKLEGMTRNIGMHAGGVLIAPG
KLTDFCPLYQQPGSESAVSQYDKDDVEAIGLVKFDFLGLATLTILEIAREFIMKRHKGQE
NFAFENIPLNDAATYRLFSEGTTEAVFQFESRGMQGMLKDARPTRLEDLIALNALYRPGP
MDLIPSFVARKHGREEVEYPHPAVAEMLSETYGIMVYQEQVMQTAQILGGYSLGGADLLR
RAMGKKKLEEMAEHREKFRAGALATHGIVQDKADEIFDLMEKFAGYGFNKSHAAAYSLLA
YHTGWLKVHYTAEFFCANMTVEMDDTDKLKLLFEDAQKNFGITFEPPDVNRGNYRFEPVT
DRVIRYGLGAVKGTGQLAVEAVVRAREEGGPFKSLFDFCVRIDRQRINKRTVEALIKAGA
FDAIQQNRASLIASVDRAFEFAIATAANASQVDIFGDCEHGSATAEPDLVDATPWGVKER
LTLEKTAVGFYLSGHLFDEVSHEVRRFCKREIGDLLDSRDQQVIAGIVSDFRVINGQRGR
LAIFKLDDKSDAIDATADEALINANRNTLKDDELVIVSGRLQPARGGFEARFQVQQVWDL
ATARCRFGKFLRVAVNGKAPDIARLIKDFPPRTEQTEVGDLIQGLPVRLSMARGGAQVEL
QLGERAKFFPTDAALASWTAQAEAGKAQIVYD