Protein Info for GFF577 in Hydrogenophaga sp. GW460-11-11-14-LB1

Annotation: Exoribonuclease II (EC 3.1.13.1)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 691 PF00773: RNB" amino acids 242 to 480 (239 residues), 109 bits, see alignment E=1.6e-35 amino acids 491 to 526 (36 residues), 33.7 bits, see alignment 1.2e-12

Best Hits

KEGG orthology group: K01147, exoribonuclease II [EC: 3.1.13.1] (inferred from 71% identity to adn:Alide_3681)

Predicted SEED Role

"Exoribonuclease II (EC 3.1.13.1)" in subsystem RNA processing and degradation, bacterial (EC 3.1.13.1)

MetaCyc Pathways

Isozymes

Compare fitness of predicted isozymes for: 3.1.13.1

Use Curated BLAST to search for 3.1.13.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (691 amino acids)

>GFF577 Exoribonuclease II (EC 3.1.13.1) (Hydrogenophaga sp. GW460-11-11-14-LB1)
MHILFDDAGKLLTGRLLSEAESSLQVELESGKRVKVKAANALLRFEKPAPGQLMTAATAL
AETMELELAYEFAPEDEFGFVDLAHEYFNDKAGTTEQVAALLCLQGAPHYFRRAGKGRYK
KAPADILAQALAAIEKKKQVQAQIEAWAAELASGSCPAPVRQQLYKILFRPDKNAPEYKA
VVEAARTSQTAPLTLLQNAGAISSAYQFHWQRFLFDQFPKGTGFPALQAPAIAEELPLAP
VQAFSIDDSQTTEIDDALSLQGLGSGSVTLGIHIAAPGLAVAPEGPIDQVARTRLSTVYM
PGHKITMLPDDVVQAYTLMAGRDCPAVSLYVSFDEATLTVTGSRTALERVPIALNLRHDQ
LDTVITEAWLAGEAPTGEAPAEIAALQPSLAFLFRLALHLKAQREVVRGKPENFTRPDYT
FRLEGVSGDEPQGDERVLIGTRKRGAPLDLMVAEAMILANSTWGNWLADCGVPGIYRSQA
SLQPGIKVRMGTKAQPHAGIGVKSYAWSTSPLRRYVDLVNQWQIIACARHGKTAALAAPF
KPKDANLFSVISAFDAAYTAYNGFQNGMERYWTLQYLRQEGITEVTATLIKDNLVRADTL
PLVLPVLGADGLPRGAHVRVKLGEIDDITLDIHGTVIERLDLPVDNADDAANDDAEDEEA
LAAPLALAIDVNETDGETAAQPPQTPGPAGD