Protein Info for GFF5762 in Hydrogenophaga sp. GW460-11-11-14-LB1

Annotation: RND multidrug efflux transporter; Acriflavin resistance protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1060 transmembrane" amino acids 12 to 30 (19 residues), see Phobius details amino acids 340 to 358 (19 residues), see Phobius details amino acids 364 to 386 (23 residues), see Phobius details amino acids 390 to 410 (21 residues), see Phobius details amino acids 435 to 460 (26 residues), see Phobius details amino acids 467 to 485 (19 residues), see Phobius details amino acids 546 to 567 (22 residues), see Phobius details amino acids 872 to 890 (19 residues), see Phobius details amino acids 901 to 921 (21 residues), see Phobius details amino acids 927 to 949 (23 residues), see Phobius details amino acids 980 to 1000 (21 residues), see Phobius details amino acids 1012 to 1035 (24 residues), see Phobius details PF00873: ACR_tran" amino acids 4 to 1035 (1032 residues), 900.4 bits, see alignment E=7.5e-275

Best Hits

KEGG orthology group: K03296, hydrophobic/amphiphilic exporter-1 (mainly G- bacteria), HAE1 family (inferred from 74% identity to pol:Bpro_1667)

Predicted SEED Role

"RND multidrug efflux transporter; Acriflavin resistance protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1060 amino acids)

>GFF5762 RND multidrug efflux transporter; Acriflavin resistance protein (Hydrogenophaga sp. GW460-11-11-14-LB1)
MWFTQVSLRNPVFATMVMIAFVVLGLFSFQRLQVDQFPNIDFPVVVVQVAYPGASPEIVE
SEVTKKVEEAVNAIAGVNTLTSRSYEGQSLVIIEFQLTVDGRKAAEDVREKIAILRPVFR
DEVEEPRVLRFDPASRSIWSVAVIPQAADGKTPSAVELTTWAEQVLKKRLENVRGVGSVT
LVGATRRAVNIDLDPSAMEALGVTPEQVNAAVRNENQDLPVGTLKAGEAERVVQLLSRLQ
NPQDFEHIIVARRGGQAVRLGQVARVSDGTQEVESLALYNGQRTLLLQVQKAQDENTIAV
TDGLKAAVAALGAELPPGVRLEQIADGSRPIRVSVENVRRTLIEGAVLTVLIVFLFLNSW
RSTVITGLTLPIALIGTFFFMNLFGFTINMITLMALTLSVGLLIDDAIVVRENIVRHVQM
GKRPFDAAMDGTQEIGLAVLATTLSIVAVFLPIGFMGGIIGKFFHEFGITMVAAVLISMF
VSFTLDPMLSSVWHDPEIEKHGHPGTGPKTLYDRTIGRVTGWFDRFQDDLSHTYQGTLRW
SLKHKLATLGLALATFVGSLFILPLLGTEFVPTADFSETSLSFHTPVGSSLEATEAKTRE
VEGILRSFPEVKYTLSTLNTGNAQGAMYASIYVRLTDRHERTLSAVEMSARLRERLRSVP
GITVTHVGLLDAVGGNKQVEFSLQGDDLAELERLTQTVMERIRPIVGLVDLDASVKPNKP
TVDVKMKRDLASDVGVSVSTVGASLRTLVAGTTVGNWRAADGQSYDVNVRLAPGGRERAS
DLEQLPFVVGTAADGTARVVRLGQVADVVDATGPNQINRRNLNREVSINANVYGRSPGEV
SAEIRQVLDAIAFPPGYRYEFGGSTKNMQESFGYAVSALALAIIFIYMILASQFQSFLQP
LALMTSLPLTLIGVALTLLMFGSSMSMFSVIGIVLLMGLVTKNAILLVDFAIRAREGRAG
EPPMDRESALLLAARVRLRPILMTTLAMVFGMVPLAFALTEGSEQRAPMGQAVIGGVITS
SLLTLVVVPVVYCYMDDLAAWFRRRLGLSIPPPAPRESTP