Protein Info for GFF55 in Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868

Annotation: [Protein-PII] uridylyltransferase (EC 2.7.7.59)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 890 TIGR01693: protein-P-II uridylyltransferase" amino acids 54 to 884 (831 residues), 988 bits, see alignment E=2.2e-301 PF01909: NTP_transf_2" amino acids 86 to 134 (49 residues), 29.4 bits, see alignment 2.1e-10 PF08335: GlnD_UR_UTase" amino acids 193 to 331 (139 residues), 155.8 bits, see alignment E=1.9e-49 PF01966: HD" amino acids 468 to 600 (133 residues), 48 bits, see alignment E=3.7e-16 PF01842: ACT" amino acids 709 to 764 (56 residues), 34.6 bits, see alignment 3.2e-12 amino acids 819 to 872 (54 residues), 35.4 bits, see alignment 1.8e-12

Best Hits

Swiss-Prot: 100% identical to GLND_SALA4: Bifunctional uridylyltransferase/uridylyl-removing enzyme (glnD) from Salmonella agona (strain SL483)

KEGG orthology group: K00990, [protein-PII] uridylyltransferase [EC: 2.7.7.59] (inferred from 94% identity to cro:ROD_01701)

Predicted SEED Role

"[Protein-PII] uridylyltransferase (EC 2.7.7.59)" in subsystem Ammonia assimilation (EC 2.7.7.59)

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.7.7.59

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (890 amino acids)

>GFF55 [Protein-PII] uridylyltransferase (EC 2.7.7.59) (Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868)
MNTLPEQHANTALPTLPDQPQNPGVWPRAELTVAGIKARIDIFQHWLGEAFDSGICAEQL
IEARTEFIDQLLQRLWIEAGFGQIADLALVAVGGYGRGELHPLSDIDLLILSRKKLPDEQ
AQKVGELLTLLWDVKLDVGHSVRTLEECLLEGLSDLTVATNLIETRLLIGDVALFLALQK
HIFSEGFWPSDKFYAAKVEEQNQRHQRYHGTSYNLEPDIKSSPGGLRDIHTLQWVARRHF
GATSLDEMVGFGFLTPAERAELNECLHILWRIRFALHLVVSRYDNRLLFDRQLSVAQRLN
YSGEGNDPVERMMKDYFRVTRRVSELNQMLLQLFDEAILALPADEKPRPVDDEFQLRGTL
IDLRDDTLFIREPQAILRMFYMMVRNSAITGIYSTTLRHLRHARRHLSQPLCYIPEARTL
FLSMLRHPGAVSRGLLPMHRHSVLWAYMPQWSHIVGQMQFDLFHAYTVDEHTIRVMLKLE
SFAKEETRQRHPLCVDLWPRLPHPELILIAALFHDIAKGRGGDHSVLGAQDVLTFAELHG
LNSRETQLVAWLVRQHLLMSVTAQRRDIQDPEVIKQFAEEVQTETRLRFLVCLTVADICA
TNETLWNSWKQSLLRELYFATEKQLRRGMQNTPDMRERVRHHQLQALALLRMDNIDEAAL
HKIWTRCRANYFVRHSPNQLAWHARHLLQHDLRQPLVLLSPQATRGGTEIFIWSPDRPYL
FAAVCAELDRRNLSVHDAQIFTTRDGMAMDTFIVLEPDGSPLAADRHDVIRTGLEQTITQ
RSWQPPQPRRQPAKLRHFTVETEVNFLPTHTDRKSFMELIALDQPGLLARVGQIFADLGI
SLHGARITTIGERVEDLFIIATADRRALNNVLQLEVQQRLTAALNPNDKG