Protein Info for GFF5485 in Hydrogenophaga sp. GW460-11-11-14-LB1

Annotation: DNA mismatch repair protein MutL

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 635 TIGR00585: DNA mismatch repair protein MutL" amino acids 14 to 332 (319 residues), 295.8 bits, see alignment E=2.5e-92 PF02518: HATPase_c" amino acids 33 to 95 (63 residues), 34.6 bits, see alignment E=4.5e-12 PF13589: HATPase_c_3" amino acids 36 to 127 (92 residues), 43.8 bits, see alignment E=5.4e-15 PF01119: DNA_mis_repair" amino acids 226 to 351 (126 residues), 118.7 bits, see alignment E=2.2e-38 PF08676: MutL_C" amino acids 449 to 591 (143 residues), 161.8 bits, see alignment E=1.7e-51

Best Hits

Predicted SEED Role

"DNA mismatch repair protein MutL" in subsystem DNA repair, bacterial MutL-MutS system

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (635 amino acids)

>GFF5485 DNA mismatch repair protein MutL (Hydrogenophaga sp. GW460-11-11-14-LB1)
VTSLPTLQTPPRRPIRELPDELISQIAAGEVVERPASVVRELVDNALDAGATQITLRLQA
GGVRLISVEDNGCGILRHELPHALKRHATSKIASLSDLESVGTMGFRGEALAAICSIAEV
SLLTRVDTADEPHGWLLDGRSGELQPTARAPGTTVEVRELFFATPARRKFLKTDATELAH
CIEAVRRHALARPDVGFAIWHEGKLVAQWRAVSGDGIDALRQRLADVLGEEFVEQAVAVD
WPIEAPILVANGQQRLRVWGFAGVPDAARSRADWQFAYVNGRYVRDKVITHAARSAYEDV
LHGHRQPVYALFVSLDPTRVDVNVHPTKIEVRFRDSREVHQGVRHAVEAALAVPRSANAA
ATDAAPAPAAAPAAPAWTPPARQAPFAFAPREPEVGHRVSDVGALWATAPSAPPLTTTSP
NAWTPPARSADPAPSQALPEGDWPLGRAIAQLQGVYILAENAHGLVVVDMHAAHERIVYE
RLKQQLDEQQLASQPLLIPATFSATPDEVATAEGCAEVLATLGLEITALSPKTMAVRAVP
TTLAQGDPVELARSVLAELGQHEASTVVQRARNELLATMACHGAVRANRRLTLDEMNALL
RQMEVTERSDQCNHGRPTWRQMGMKELDALFLRGR