Protein Info for GFF546 in Sphingobium sp. HT1-2

Annotation: Acetaldehyde dehydrogenase, acetylating, (EC 1.2.1.10) in gene cluster for degradation of phenols, cresols, catechol

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR03215: acetaldehyde dehydrogenase (acetylating)
  • amino acids 5 to 308 (304 residues), 456.1 bits, E=2.3e-141
• PF01118: Semialdhyde_dh
  • amino acids 7 to 120 (114 residues), 31.1 bits, E=2.8e-11
• PF09290: AcetDehyd-dimer
  • amino acids 131 to 284 (154 residues), 198.7 bits, E=4.7e-63

Best Hits

Swiss-Prot: 72% identical to ACDH3_PARXL: Acetaldehyde dehydrogenase 3 (Bxeno_B0694) from Paraburkholderia xenovorans (strain LB400)

KEGG orthology group: K04073, acetaldehyde dehydrogenase [EC: 1.2.1.10] (inferred from 72% identity to bxe:Bxe_B2326)

MetaCyc: 70% identical to acylating aldehyde dehydrogenase (Pseudomonas putida F1)
Acetaldehyde dehydrogenase (acetylating). [EC: 1.2.1.10]

Predicted SEED Role

"Acetaldehyde dehydrogenase, acetylating, (EC 1.2.1.10) in gene cluster for degradation of phenols, cresols, catechol" in subsystem Biphenyl Degradation or Central meta-cleavage pathway of aromatic compound degradation (EC 1.2.1.10)

MetaCyc Pathways

• heterolactic fermentation (16/18 steps found)
• mixed acid fermentation (13/16 steps found)
• hexitol fermentation to lactate, formate, ethanol and acetate (15/19 steps found)
• 2-hydroxypenta-2,4-dienoate degradation (3/3 steps found)
• L-threonine degradation IV (2/2 steps found)
• ethanol degradation I (2/2 steps found)
• acetylene degradation (anaerobic) (4/5 steps found)
• ethanolamine utilization (4/5 steps found)
• superpathway of L-threonine metabolism (13/18 steps found)
• pyruvate fermentation to ethanol I (2/3 steps found)
• pyruvate fermentation to ethanol III (2/3 steps found)
• superpathway of fermentation (Chlamydomonas reinhardtii) (6/9 steps found)
• catechol degradation I (meta-cleavage pathway) (3/5 steps found)
• superpathway of N-acetylneuraminate degradation (15/22 steps found)
• 2-aminoethylphosphonate degradation I (1/3 steps found)
• 2-deoxy-α-D-ribose 1-phosphate degradation (1/3 steps found)
• 2-deoxy-D-ribose degradation I (1/3 steps found)
• sulfoacetaldehyde degradation IV (1/3 steps found)
• superpathway of pyrimidine deoxyribonucleosides degradation (3/6 steps found)
• mandelate degradation to acetyl-CoA (11/18 steps found)
• catechol degradation II (meta-cleavage pathway) (3/7 steps found)
• toluene degradation I (aerobic) (via o-cresol) (3/7 steps found)
• toluene degradation V (aerobic) (via toluene-cis-diol) (3/7 steps found)
• meta cleavage pathway of aromatic compounds (5/10 steps found)
• 3-phenylpropanoate and 3-(3-hydroxyphenyl)propanoate degradation (3/8 steps found)
• p-cumate degradation (3/8 steps found)
• superpathway of purine deoxyribonucleosides degradation (2/7 steps found)
• superpathway of Clostridium acetobutylicum acidogenic and solventogenic fermentation (9/17 steps found)
• triethylamine degradation (1/6 steps found)
• superpathway of Clostridium acetobutylicum solventogenic fermentation (6/13 steps found)
• naphthalene degradation to acetyl-CoA (5/12 steps found)
• toluene degradation IV (aerobic) (via catechol) (5/13 steps found)
• L-tryptophan degradation IX (4/12 steps found)
• L-tryptophan degradation XII (Geobacillus) (4/12 steps found)
• p-cymene degradation (3/11 steps found)
• superpathway of aromatic compound degradation via 3-oxoadipate (17/35 steps found)
• superpathway of aerobic toluene degradation (10/30 steps found)
• superpathway of aromatic compound degradation via 2-hydroxypentadienoate (13/42 steps found)

KEGG Metabolic Maps

• Butanoate metabolism
• Pyruvate metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.2.1.10

Protein Sequence (314 amino acids)

>GFF546 Acetaldehyde dehydrogenase, acetylating, (EC 1.2.1.10) in gene cluster for degradation of phenols, cresols, catechol (Sphingobium sp. HT1-2)
VAQKRMKVAIIGSGNIGTDLMIKVMRQSDVLEMSALVGIDPQSDGLARAARMGVATTHEG
MDGLQRLDVWSQIGLVFDATSAGAHPQHSTIVTGAGKAMIDLTPAAIGPYVIPVVNGDAH
LDAANVNMVTCGGQATIPIVAAISAVATVHYAEIVASIASKSAGPGTRANIDEFTETTSR
AIEEVGGAHKGKAIIVLNPAEPPMLMRDTVFVLSSGASEAEIAAAVEAMVARVAAYVPGY
RLKQQVQFERFGANNPVQIPGLGQFEGIKSTIFLEVEGAAHYLPAYAGNLDIMTSAALAT
AEKIAARRLLQEAV