Protein Info for GFF5421 in Variovorax sp. SCN45

Annotation: Peptidase M48, Ste24p precursor

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 521 signal peptide" amino acids 1 to 40 (40 residues), see Phobius details transmembrane" amino acids 126 to 141 (16 residues), see Phobius details amino acids 175 to 190 (16 residues), see Phobius details PF01435: Peptidase_M48" amino acids 84 to 279 (196 residues), 106 bits, see alignment E=1.1e-34

Best Hits

KEGG orthology group: None (inferred from 87% identity to vpe:Varpa_5897)

Predicted SEED Role

"Exported zinc metalloprotease YfgC precursor"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (521 amino acids)

>GFF5421 Peptidase M48, Ste24p precursor (Variovorax sp. SCN45)
MPRLTPTPSRKRRITPALRTFCATFLIASQVLLPAPALAQMQVLPGLGDGGEMTASAERH
LGDQIARELYRDTDYIDDPVVAAYVQDIWQRLLAAARARGELTPELDERFAWTILLGRDR
NINAFALPGGYLGLNLGLVAAVGSRDELATVLGHELSHVTQRHISRIMSKQGKQMPLMIA
GLILGMIAASKSRSGDAGQAVMMGSQAVFAQNQLNFSRDMEREADRVGFGVMTQAGFAPQ
GAAAMFEKLQYASRLNDNGSYPYLRSHPLTTERISDMQGRFQFKMDTTPPLPLVMDHAMI
ASRARVLTRPGVDVLRLWVDSASSGEVAKSSPAQQAGTLYAAALSAKELRDYKAARALVE
RLVARTAEDLAAAKQARWLSAEIELAAGAPAKAAALLDAKSKERPEMMLAAEAATAMRQP
APMIPVLRDWVAANPRDATAWHALANLYGAENDTLRAVRADAEANVAILDYPAARDRFKA
AQELIRQSNKPVDHYEASIIDTRARAVDVLVKEQAAEPPLK