Protein Info for GFF5383 in Hydrogenophaga sp. GW460-11-11-14-LB1

Annotation: Choline dehydrogenase (EC 1.1.99.1)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 532 PF00732: GMC_oxred_N" amino acids 4 to 293 (290 residues), 174 bits, see alignment E=8.3e-55 PF05199: GMC_oxred_C" amino acids 385 to 518 (134 residues), 128.9 bits, see alignment E=4.3e-41

Best Hits

KEGG orthology group: None (inferred from 73% identity to ctt:CtCNB1_1927)

Predicted SEED Role

"Choline dehydrogenase (EC 1.1.99.1)" in subsystem Choline and Betaine Uptake and Betaine Biosynthesis (EC 1.1.99.1)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.1.99.1

Use Curated BLAST to search for 1.1.99.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (532 amino acids)

>GFF5383 Choline dehydrogenase (EC 1.1.99.1) (Hydrogenophaga sp. GW460-11-11-14-LB1)
MDSYDYIIVGGGTAGCVLANRLTASGRHRVLMLEAGGEPKSMWINIPAGFSKLLTNRQYN
WRFQTEAEDNTNGRVISVPRGKGLGGSTLINGMIYVRGQPGDYDAWRDTGARGWSFEDVE
PYFRKLERCKEGGPTRGHAGPMRLEKVRERFPISDAFIQAANEDGLPFNDDYNAERQDGV
GYYEVTQSGGRRWSAYKGYLEPALQRKNLKVVTDAQVLRVDLAGKRCTGVTYRKGGQDVT
VKAGIEVILAAGAIQSPQILELSGIGQPELLKRLGIPVEHALEGVGENYIDHFATRMNWR
VKGTVTLNEMSRNWRLGLAVSQYFAKRTGILTLGTGLVNAFVRTRPEMATPDAQFFFVHA
SYKNAAERVLDRQPGMTIGVTQLRPQSIGSIHIKSRDVSAGPSIRPNFLSSTVDQECMVR
SMEIARRIVTRPAMKKYVVEEMSPGENVKSDADWLAFARANGQTIYHPIGTCRMGDDDLA
VVDPRLKVRGLQGLRVVDASVMPKMVSGNIQAAVMMVAERGADLVLEDAVGQ