Protein Info for GFF5370 in Variovorax sp. SCN45

Annotation: TPR domain protein, putative component of TonB system

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 829 PF13174: TPR_6" amino acids 20 to 49 (30 residues), 16.3 bits, see alignment (E = 1.1e-05) PF13424: TPR_12" amino acids 22 to 79 (58 residues), 30.9 bits, see alignment 2.4e-10 amino acids 299 to 361 (63 residues), 40.9 bits, see alignment 1.8e-13 PF13432: TPR_16" amino acids 22 to 82 (61 residues), 40.9 bits, see alignment 2e-13 amino acids 128 to 185 (58 residues), 26.5 bits, see alignment 6.4e-09 amino acids 199 to 245 (47 residues), 17.3 bits, see alignment 4.9e-06 amino acids 280 to 330 (51 residues), 23.2 bits, see alignment 6.8e-08 amino acids 310 to 364 (55 residues), 30.5 bits, see alignment 3.6e-10 PF14559: TPR_19" amino acids 30 to 83 (54 residues), 30.1 bits, see alignment 4.5e-10 amino acids 97 to 155 (59 residues), 25.5 bits, see alignment 1.2e-08 amino acids 199 to 244 (46 residues), 26.8 bits, see alignment 4.7e-09 amino acids 311 to 366 (56 residues), 35.5 bits, see alignment 9.1e-12 PF13181: TPR_8" amino acids 119 to 150 (32 residues), 15 bits, see alignment (E = 2.1e-05) amino acids 154 to 183 (30 residues), 16.2 bits, see alignment (E = 8.4e-06) amino acids 302 to 330 (29 residues), 19.5 bits, see alignment (E = 7.3e-07) amino acids 335 to 364 (30 residues), 13.4 bits, see alignment (E = 6.6e-05) PF07719: TPR_2" amino acids 152 to 183 (32 residues), 23.8 bits, see alignment (E = 3.1e-08) amino acids 301 to 331 (31 residues), 26.5 bits, see alignment (E = 4.2e-09) PF13374: TPR_10" amino acids 301 to 329 (29 residues), 21.9 bits, see alignment (E = 1.2e-07) PF00515: TPR_1" amino acids 301 to 331 (31 residues), 29.7 bits, see alignment (E = 3.8e-10) PF13428: TPR_14" amino acids 302 to 340 (39 residues), 24.1 bits, see alignment 3.4e-08 PF13414: TPR_11" amino acids 310 to 347 (38 residues), 34.6 bits, see alignment 1.1e-11 PF13431: TPR_17" amino acids 322 to 353 (32 residues), 24.2 bits, see alignment (E = 2.6e-08) PF13844: Glyco_transf_41" amino acids 448 to 606 (159 residues), 150.7 bits, see alignment E=4.2e-47 amino acids 613 to 797 (185 residues), 155.2 bits, see alignment E=1.8e-48

Best Hits

KEGG orthology group: None (inferred from 81% identity to vpe:Varpa_1276)

Predicted SEED Role

"TPR domain protein, putative component of TonB system" in subsystem Ton and Tol transport systems

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (829 amino acids)

>GFF5370 TPR domain protein, putative component of TonB system (Variovorax sp. SCN45)
MNSPSLAPAPTASADEASRLLEQGLTQHRMGRFTEALRIYENLLSQFPEHADALHLTGEA
LYRQGRPKLALNYVNRAIAKSPHHFYFNTRATIFMHMGLLAEAQQDLRRAIKALPNYPEA
YVNLSAVYRQQKKFRQAREAAGEATRLAPQSPAAWNNAGAIDMEQDRLEEAVEQFRQALK
LDSGYIAAHKNIGKIRAHQKDWAGALTSLEQAQTDPPDFEAAYLLSRALIACGRNEEAIA
PMQRAMRHSTVEVRARALSDPEAVAALYGVCAALEGAAMRFDESEELYKLALESMPEQEA
LLNNLGATNFRQGRYDAAIEVLKKALELHPRQVLARCNLGVTYVMAGQSEAAIAEFEQCL
RDDPDFMPAMVWLLGEKAHIARWEGVPELRAKIAARLDNPVDDQTASSFILMSNYDDAHR
LMHWTQRSATLADRNTAIKPFADAGARRTSPRIRVGYYSFDFRNHPVAHLTAELYSLHDR
KDFEVFVYSYGPDDGHPARARIAASAEHFVDMHGQSIQQMAERIREDEIDILVDLSGDTR
GAKPQVMAYHTAPAQLMWLGYMGTSGSTNYDYLVSDGFLSPQGTEDCYTEKLLRLPETFQ
VIDTKRPVNPHKATREAHGLPEDAFVLCNFSQSFKIQPETFDAWVRIVRGIPNSVLWLAQ
GPNGFERNLRAHWEKAGLPAERLIVSPRMPVDQHLARIGLADLFIDTFPYSSGATANDVL
WSGVPLLALTGSTMVSRMAGSLLGAIGLPELVATNHAEYVQKAIHYATHPDELAALRARL
AAAKEARRGYFDTPRFVRHLEDGFRQIAARSREGLPTAHVDVALRPPGK