Protein Info for GFF5366 in Variovorax sp. SCN45

Annotation: L-Proline/Glycine betaine transporter ProP

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 transmembrane" amino acids 38 to 57 (20 residues), see Phobius details amino acids 69 to 90 (22 residues), see Phobius details amino acids 100 to 121 (22 residues), see Phobius details amino acids 123 to 123 (1 residues), see Phobius details amino acids 129 to 152 (24 residues), see Phobius details amino acids 164 to 187 (24 residues), see Phobius details amino acids 199 to 218 (20 residues), see Phobius details amino acids 253 to 275 (23 residues), see Phobius details amino acids 289 to 311 (23 residues), see Phobius details amino acids 319 to 336 (18 residues), see Phobius details amino acids 348 to 370 (23 residues), see Phobius details amino acids 382 to 404 (23 residues), see Phobius details amino acids 410 to 430 (21 residues), see Phobius details PF00083: Sugar_tr" amino acids 30 to 240 (211 residues), 78 bits, see alignment E=7.3e-26 PF07690: MFS_1" amino acids 69 to 394 (326 residues), 95.9 bits, see alignment E=2.4e-31

Best Hits

KEGG orthology group: None (inferred from 93% identity to vpe:Varpa_1272)

Predicted SEED Role

"L-Proline/Glycine betaine transporter ProP" in subsystem Proline, 4-hydroxyproline uptake and utilization

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (450 amino acids)

>GFF5366 L-Proline/Glycine betaine transporter ProP (Variovorax sp. SCN45)
MTPEATLPDGAQPAPARTLGTSDYKTLALSALGGTLEFYDFVIYVFFATVLGALFFPTDM
PDWLRQLQTFGIFAAGYLARPVGGIVIAHFGDIFGRKRMFTLSIFLMAAPTLVIGLLPTY
ASIGVAAPLLLLLMRVLQGAAIGGEMPGAWVFVGEHVPARRYGFGIGMLTSGITGGILLG
SLIAVAINRHYSPEQVSDFAWRIPFILGGVFGLVSVYLRRFLHETPVFKELAGRRSVARE
LPLRTVLREHRLACVYVALLTWVLSAAIVVVVLYTPTYLQKVHHIPAALSLEANALATLT
LTLGCMLAGWASDRFGTRTVMLVGWGGLFATAYLFYTGLPGTPATLFWHYGLVGLFVGTI
ATVPIAGVRAFPAPVRFTGLSFAYNMSYAVFGGLTPVILTLWLQHDTMAPAHYVAVLAAL
GFLLALLPLAVRGHAMRDGVAPAGRATMSR