Protein Info for GFF5273 in Variovorax sp. SCN45

Annotation: Various polyols ABC transporter, permease protein 1

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 285 transmembrane" amino acids 12 to 33 (22 residues), see Phobius details amino acids 68 to 90 (23 residues), see Phobius details amino acids 100 to 119 (20 residues), see Phobius details amino acids 151 to 173 (23 residues), see Phobius details amino acids 208 to 228 (21 residues), see Phobius details amino acids 256 to 277 (22 residues), see Phobius details PF00528: BPD_transp_1" amino acids 81 to 282 (202 residues), 60.7 bits, see alignment E=8.1e-21

Best Hits

KEGG orthology group: K10228, sorbitol/mannitol transport system permease protein (inferred from 97% identity to vpe:Varpa_1192)

MetaCyc: 64% identical to polyol ABC-type transporter permease component MtlF (Pseudomonas fluorescens)
7.5.2.M2 [EC: 7.5.2.M2]; 7.5.2.M2 [EC: 7.5.2.M2]; 7.5.2.M2 [EC: 7.5.2.M2]

Predicted SEED Role

"Various polyols ABC transporter, permease component 1" in subsystem Ribitol, Xylitol, Arabitol, Mannitol and Sorbitol utilization

Isozymes

No predicted isozymes

Use Curated BLAST to search for 7.5.2.M2

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (285 amino acids)

>GFF5273 Various polyols ABC transporter, permease protein 1 (Variovorax sp. SCN45)
MKRLLPRALMAPAVLTLFLWMIVPLLMTLYFSFVNYNLMQPGERTFAGIENFHYFVTDPD
FWPATWNTLLLIGSVIVITVVLGVLLALLVNEPFPGRGIVRVLLISPFFVMPAVNALLWK
HMMMNPIYGVLADLWRFFGAQPVDWLTDFPLLSVIIMVAWQWLPFACLIFITSLQSLDRE
QMEAARMDGASPVQRFFYLTIPHLGRPMAVVIMIEMIFLLSVFAEIAITTNGGPGNASTN
MTYMIFKQSLMNFDVGVASAGALFAVVLANIVAVFLIRMIGKNLD