Protein Info for GFF5259 in Variovorax sp. SCN45

Annotation: Na+/solute symporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 501 transmembrane" amino acids 6 to 27 (22 residues), see Phobius details amino acids 55 to 79 (25 residues), see Phobius details amino acids 83 to 103 (21 residues), see Phobius details amino acids 131 to 151 (21 residues), see Phobius details amino acids 160 to 182 (23 residues), see Phobius details amino acids 192 to 212 (21 residues), see Phobius details amino acids 245 to 269 (25 residues), see Phobius details amino acids 282 to 304 (23 residues), see Phobius details amino acids 326 to 354 (29 residues), see Phobius details amino acids 375 to 396 (22 residues), see Phobius details amino acids 404 to 423 (20 residues), see Phobius details amino acids 430 to 447 (18 residues), see Phobius details amino acids 467 to 487 (21 residues), see Phobius details PF00474: SSF" amino acids 47 to 434 (388 residues), 78.4 bits, see alignment E=2.5e-26

Best Hits

Swiss-Prot: 73% identical to MCTP_RHIL3: Monocarboxylate transport permease protein (mctP) from Rhizobium leguminosarum bv. viciae (strain 3841)

KEGG orthology group: K03307, solute:Na+ symporter, SSS family (inferred from 84% identity to rpi:Rpic_3821)

Predicted SEED Role

"Acetate permease ActP (cation/acetate symporter)" in subsystem Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (501 amino acids)

>GFF5259 Na+/solute symporter (Variovorax sp. SCN45)
MAGQINWTALSVFVFFFLLVTVMGFWASRWQSGGAKGKGAHLDEWGLGGRNFGTWITWFL
VGGDFYTAYTVIAVPALVYAVGAYGFFALPYTILVYPIVFIIMPRLWHAAHKAGHVTAAD
VVYGRYGSRALELAIAVTGVVATMPYIALQLVGMEVVIKALGLTGELPLAAAFVILALYT
YSAGLRAPALIAFVKDLMIYIVVLVAVVLVPMKLGGYGSVFHAAGDAFAAKGGATGLTLK
PAQYLPYASLALGSALAAFMYPHTLTGIFAAKSANTIRKNAVFLPAYTVLLGLIALLGYM
AYAAHLTVKSNNDVVPALFNALFPSWFAGFAFAAIAIGALVPAAVMSIGAANLFTRNFWK
AYVRPDVTPAGEARVAKIVSLVVKLGALVFILFLPTQFALDLQLLGGLWILQTFPAVVFG
LFFGWFRAPALLAGWAVGLAGGSWLAFSDGIKPVHTFVIGGDSFTLYTGLAALALNIVVA
VVVQLVVKGAPLREQPALAGR